The effect of l-lactide-ε-caprolactone copolymer membrane on alveolar bone preservation: A comparative study using the open healing approach

IF 3.5 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-05-13 DOI:10.1016/j.reth.2025.04.007

Masayuki Takabayashi , Yoshio Yahata , Keisuke Handa , Moe Sandar Kyaw , Venkata Venkataih Suresh , Masahiro Saito

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引用次数: 0

Abstract

Introduction

This study evaluated the efficacy of a resorbable l-lactide-ε-caprolactone copolymer (PLCL) membrane in promoting epithelial healing and preserving alveolar bone morphology using the open healing approach (OHA), compared to conventional membranes.

Methods

Extraction sockets in beagle dogs were filled with bone substitute material and covered with different membranes. Healing was assessed via histological analysis and micro-CT imaging.

Results

The PLCL membrane reduced bone resorption and preserved alveolar bone morphology better than conventional membranes. Histological analysis showed excellent epithelial healing and notable bone formation.

Conclusions

The PLCL membrane effectively prevents infection, supports epithelial healing, and preserves alveolar bone morphology in OHA procedures.

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l-丙交酯-ε-己内酯共聚物膜对牙槽骨保存的影响：与开放愈合方法的比较研究

本研究评估了可吸收l-丙交酯-ε-己内酯共聚物（PLCL）膜在开放式愈合方法（OHA）中促进上皮愈合和保存牙槽骨形态的功效，与传统膜相比。方法用骨替代物填充beagle犬的牵引槽，并覆盖不同的膜。通过组织学分析和显微ct成像评估愈合情况。结果与常规膜相比，PLCL膜能更好地减少骨吸收，保存牙槽骨形态。组织学分析显示良好的上皮愈合和显著的骨形成。结论在OHA手术中，PLCL膜可有效预防感染，支持上皮愈合，并保留牙槽骨形态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.