{"title":"Exploring the potential of herbal bioactives to treat acne: A perspective review","authors":"Pratibha Dhiwar , Trilochan Satapathy , Arun Kumar Sahu , Nikita Patel","doi":"10.1016/j.prenap.2025.100260","DOIUrl":null,"url":null,"abstract":"<div><div>Millions of individuals worldwide suffer from acne, a common skin ailment that is frequently caused by hormonal imbalance, bacterial infections, inflammation, and excessive sebum production. Despite their effectiveness, conventional therapies can result in antibiotic resistance and adverse consequences. The potential of herbal bioactive substances as an alternate therapeutic strategy for acne treatment is examined in this review. Numerous medicinal herbs those are high in antibacterial, anti-inflammatory, and antioxidant compounds have demonstrated potential in minimizing the symptoms of acne. Important bioactive from plants like tea tree, Aloe vera, and neem, containing flavonoids, alkaloids, and essential oils, have demonstrated strong anti-acne effects by regulating sebum production, preventing Propionibacterium acnes, and accelerating skin healing. In this review, the authors tried to explore the safety profile and therapeutic applications of potent herbal bioactives for the treatment of acne. The authors also expect that, the information containing in this review will pave the way and helpful for the researchers engaged in the field of acne and associated skin disorders.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100260"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S295019972500120X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Millions of individuals worldwide suffer from acne, a common skin ailment that is frequently caused by hormonal imbalance, bacterial infections, inflammation, and excessive sebum production. Despite their effectiveness, conventional therapies can result in antibiotic resistance and adverse consequences. The potential of herbal bioactive substances as an alternate therapeutic strategy for acne treatment is examined in this review. Numerous medicinal herbs those are high in antibacterial, anti-inflammatory, and antioxidant compounds have demonstrated potential in minimizing the symptoms of acne. Important bioactive from plants like tea tree, Aloe vera, and neem, containing flavonoids, alkaloids, and essential oils, have demonstrated strong anti-acne effects by regulating sebum production, preventing Propionibacterium acnes, and accelerating skin healing. In this review, the authors tried to explore the safety profile and therapeutic applications of potent herbal bioactives for the treatment of acne. The authors also expect that, the information containing in this review will pave the way and helpful for the researchers engaged in the field of acne and associated skin disorders.