Mn(OAc)3 promoted radical cyclization of vinyl isocyanides: Synthesis of isoquinoline-1-sulfonates and derivatives

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-03 DOI:10.1016/j.tetlet.2025.155629

Xin Gu , Yan Zhang , Ruiming Zhang , Yijie Wang , Shuai Liang , Yongmei Xie

引用次数: 0

Abstract

This study presents a Mn(OAc)₃-promoted radical cyclization of vinyl isocyanides to efficiently synthesize 1-functionalized isoquinolines. Using the Mn(OAc)₃-K₂S₂O₅-HFIP system, 13 isoquinoline-1-sulfonates were prepared in good yields under mild conditions. These sulfonates were further converted into 1-chloro, 1-methoxy, 1-phenoxy, and 1-amino isoquinolines, demonstrating their potential as versatile intermediates.

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Mn(OAc)3促进乙烯基异氰酸酯的自由基环化：异喹啉磺酸盐及其衍生物的合成

本文研究了Mn(OAc)3促进乙烯基异氰酸酯自由基环化，以高效合成1官能化异喹啉。采用Mn(OAc)3-K2S2O5-HFIP体系，在温和条件下以较高的收率制备了13种异喹啉-1-磺酸盐。这些磺酸盐进一步转化为1-氯、1-甲氧基、1-苯氧基和1-氨基异喹啉，显示了它们作为多功能中间体的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.