Base-promoted [3+2]-cycloaddition of N-alkoxy-4-oxo-acrylamides with isatins for stereoselective synthesis of spirooxindole-2-oxazolidinones

Abstract

We have developed a novel base-promoted [3+2]-cycloaddition reaction between N-alkoxy-4-oxo-acrylamides and isatins. This method provides a practical and efficient protocol for synthesizing biologically relevant spirooxindole-2-oxazolidinones under mild conditions. The reaction proceeds with moderate to good yields and diastereoselectivities, showcasing its utility for constructing complex spirooxindole frameworks.