Advances in harnessing biological macromolecules for periodontal tissue regeneration: A review

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-05-07 DOI:10.1016/j.ijbiomac.2025.144031

Dongyi Yang , Dong He , Fanlei Yang , Xiangyou Meng , Kai Zheng , Haitao Lin , Yi Cheng , Wai Cheong Tam , Gang Li

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Abstract

Periodontitis is a chronic multifactorial inflammatory oral disease that can lead to gingival recession, destruction of the periodontal ligament, alveolar bone loss, and tooth loss. Solutions for periodontal tissue regeneration utilize biological macromolecules, including natural ones (such as collagen (COL), alginate (ALG), chitosan (CS), silk fibroin (SF), hyaluronic acid (HA), etc.), inorganic ones (such as hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP), bioactive glass (BG), etc.), synthetic, composite, and nanomaterials. Carrier materials, including hydrogels, nanofibers, nanoparticles, microneedles, and thin films, are used to effectively deliver therapeutic agents and biological factors such as stem cells, bioactive molecules, and genes, so as to promote the elimination of bacteria and tissue regeneration at the damaged periodontal sites. This review mainly focuses on the latest progress of biological macromolecules and tissue engineering technologies in periodontal regeneration in recent years. It aims to inspire the design and development of innovative biomaterials and delivery systems for novel regenerative periodontal treatments.

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生物大分子在牙周组织再生中的应用进展

牙周炎是一种慢性多因素炎症性口腔疾病，可导致牙龈萎缩、牙周韧带破坏、牙槽骨丢失和牙齿脱落。牙周组织再生解决方案利用生物大分子，包括天然大分子（如胶原蛋白（COL）、海藻酸盐（ALG）、壳聚糖（CS）、丝素蛋白（SF）、透明质酸（HA）等）、无机大分子（如羟基磷灰石（HAp）、β-磷酸三钙（β-TCP）、生物活性玻璃（BG）等）、合成材料、复合材料和纳米材料。载体材料包括水凝胶、纳米纤维、纳米粒子、微针、薄膜等，可有效地递送治疗剂和生物因子，如干细胞、生物活性分子、基因等，从而促进受损牙周部位的细菌清除和组织再生。本文主要综述了近年来生物大分子和组织工程技术在牙周再生中的最新进展。它的目的是激发设计和开发创新的生物材料和输送系统，用于新的再生牙周治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.