Phenotypic resistance to ivermectin in Hyalomma anatolicum populations from north-western state of Punjab, India

IF 1.4 Q3 PARASITOLOGY

Veterinary parasitology, regional studies and reports Pub Date : 2025-05-07 DOI:10.1016/j.vprsr.2025.101278

Jyoti, Manisha, Harkirat Singh, Nirbhay Kumar Singh

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Abstract

Hyalomma anatolicum is a multi-host ixodid tick species that significantly contributes to the spread of pathogens, posing economic and health challenges for livestock populations. This study assessed the acaricide resistance status to ivermectin in H. anatolicum field populations from north-western state of Punjab, India by larval immersion test. Dose-mortality response was analysed using probit transformation of percent mortality and logarithmically transformed drug concentrations, and lethal concentration (LC₅₀, LC₉₀ and LC₉₉) and resistance ratio values were determined. Bioassay results revealed resistance status against ivermectin in all studied field isolates with RR₅₀ values ranging from 8.87 to 95.22. The maximum value was recorded in MKS (RR₅₀ = 95.22), followed by FKA (RR₅₀ = 48.78) and minimum in BNN isolate (RR₅₀ = 8.87). The findings highlight a concerning trend of resistance development in field isolates of multi-host cattle tick from Punjab state and thereby emphasizing the need for resistance management strategies, including integrated tick management practices, rotational use of acaricides and adoption of alternative control measures.

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印度旁遮普邦西北部安纳托利透明眼种群对伊维菌素的表型耐药

anatolicum透明眼蜱是一种多宿主蜱，对病原体的传播起着重要作用，对牲畜种群构成经济和健康挑战。本研究采用幼虫浸渍法对印度西北部旁遮普邦anatolicum田间种群对伊维菌素的抗性状况进行了评价。采用死亡率百分比概率转化和对数转化药物浓度分析剂量-死亡率反应，测定致死浓度（LC50、LC90和LC99）和耐药比值。生物测定结果显示所有野外分离株对伊维菌素的耐药状况，RR50值在8.87 ~ 95.22之间。MKS最高（RR50 = 95.22）， FKA次之（RR50 = 48.78）， BNN分离株最低（RR50 = 8.87）。研究结果强调了旁遮普邦多宿主牛蜱田间分离物的耐药性发展趋势，因此强调了耐药性管理战略的必要性，包括蜱类综合管理实践、轮流使用杀螨剂和采用替代控制措施。

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来源期刊

Veterinary parasitology, regional studies and reports Multiple-

CiteScore

2.90

自引率

7.10%

发文量

126

审稿时长

97 days

期刊介绍： Veterinary Parasitology: Regional Studies and Reports focuses on aspects of veterinary parasitology that are of regional concern, which is especially important in this era of climate change and the rapid and often unconstrained travel of people and animals. Relative to regions, this journal will accept papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites within the field of veterinary medicine. Also, case reports will be considered as they add to information related to local disease and its control; such papers must be concise and represent appropriate medical intervention. Papers on veterinary parasitology from wildlife species are acceptable, but only if they relate to the practice of veterinary medicine. Studies on vector-borne bacterial and viral agents are suitable, but only if the paper deals with vector transmission of these organisms to domesticated animals. Studies dealing with parasite control by means of natural products, both in vivo and in vitro, are more suited for one of the many journals that now specialize in papers of this type. However, due to the regional nature of much of this research, submissions may be considered based upon a case being made by the author(s) to the Editor. Circumstances relating to animal experimentation must meet the International Guiding Principles for Biomedical Research Involving Animals as issued by the Council for International Organizations of Medical Sciences (obtainable from: Executive Secretary C.I.O.M.S., c/o W.H.O., Via Appia, CH-1211 Geneva 27, Switzerland).