Better the devil you know than the devil you don’t — PEG challenges in nanomedicine

IF 38.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nature nanotechnology Pub Date : 2025-05-13 DOI:10.1038/s41565-025-01925-0

Marina A. Dobrovolskaia

引用次数: 0

Abstract

Mass vaccination using polyethylene glycol (PEG)-containing nanoparticles during the COVID-19 pandemic has resulted in cases of adverse reactions, bringing to the fore the issue of PEG immunogenicity and reinforcing the view that this polymer should be substituted with other stealth-inducing molecules. Before considering alternatives, however, it is crucial to carry out more detailed analyses of the anti-PEG antibodies, to standardize the procedures for their detection and to better contextualize their generation within different nanoformulations, routes of administration, indication, safety and efficacy. The resulting studies could guide both the future use of PEGylated nanomedicines and the synthesis of the next generation of PEG or its alternatives.

Abstract Image

查看原文本刊更多论文

知道的魔鬼总比不知道的魔鬼好——纳米医学中的聚乙二醇挑战

在COVID-19大流行期间，使用含有聚乙二醇（PEG）的纳米颗粒进行大规模疫苗接种已导致不良反应病例，使聚乙二醇免疫原性问题凸显出来，并加强了这种聚合物应被其他诱导隐身的分子取代的观点。然而，在考虑替代方案之前，至关重要的是对抗peg抗体进行更详细的分析，使其检测程序标准化，并更好地了解其在不同纳米制剂、给药途径、适应症、安全性和有效性中的产生。由此产生的研究可以指导聚乙二醇化纳米药物的未来使用以及下一代聚乙二醇或其替代品的合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature nanotechnology 工程技术-材料科学：综合

CiteScore

59.70

自引率

0.80%

发文量

196

审稿时长

4-8 weeks

期刊介绍： Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.