Serum Concentration of Selected Per- and Polyfluoroalkyl Substances (PFAS) by Industry and Occupational Groups Among US Adult Workers, NHANES 2005–2014

IF 2.7 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American journal of industrial medicine Pub Date : 2025-04-28 DOI:10.1002/ajim.23726

Ja K. Gu, Luenda E. Charles, Chol Seung Lim, Anna Mnatsakanova, Stacey Anderson, Lisa Dzubak, Erin McCanlies

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引用次数: 0

Abstract

Purpose

Per- and polyfluoroalkyl substances (PFAS) are associated with multiple health effects including pregnancy-induced hypertension and pre-eclampsia, increased serum hepatic enzymes, increased in serum lipids, decreased antibody response to vaccines, and decreased birth weight. Millions of US workers are exposed to PFAS at their workplaces. Our objective was to estimate the serum levels of the five PFAS that are most frequently detected in the US general population(perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDA), and perfluorononanoic acid (PFNA)) among US adult workers.

Methods

Participants were 4476 workers aged ≥ 20 years with PFAS analyte results available who participated in the National Health and Nutrition Examination Survey (NHANES), 2005–2014. Geometric mean serum levels of PFAS (ng/mL) were obtained across industry and occupation groups using the PFAS subsample weight in SAS-callable SUDAAN V11.

Results

Among 21 industry groups, the highest geometric mean PFAS levels (ng/mL) were observed in Construction (PFOS = 12.61 ng/mL, PFOA = 3.76, PFHxS = 2.10, PFNA = 1.23, and PFDA = 0.33), followed by Utilities (PFOS = 12.46), and Real Estate/Rental/Leasing (PFOS = 12.15). The lowest geometric mean PFAS levels were seen in Private Households (PFOS = 6.34, PFOA = 2.12, PFHxS=0.75, PFNA = 0.86, and PFDA = 0.25). Among 22 occupation groups, the highest geometric mean PFAS levels were observed in Life/Physical/Social Science occupations (PFOS = 13.19, PFOA = 3.54, PFHxS= 1.69, PFNA = 1.23, and PFDA = 0.33), followed by Installation/Maintenance/Repair occupations (PFOS = 12.75), and Construction/Extraction occupations (PFOS = 12.15). The lowest geometric mean PFAS levels were found in Personal Care/Service occupations (PFOS = 7.25, PFOA = 2.43, PFHxS = 1.07, PFNA = 0.94, and PFDA = 0.25).

Conclusions

Some industry and occupation groups had higher geometric mean levels of PFAS in serum compared to others. Further investigation of these industries and occupations may result in a better understanding of the sources and degree of occupational exposure to PFAS.

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NHANES 2005-2014，美国成年工人中按行业和职业分类的选定全氟烷基和多氟烷基物质（PFAS）的血清浓度

全氟烷基和多氟烷基物质（PFAS）与多种健康影响有关，包括妊娠高血压和先兆子痫、血清肝酶升高、血脂升高、对疫苗的抗体反应降低和出生体重下降。数以百万计的美国工人在工作场所接触到PFAS。我们的目的是估计美国成年工人中最常检测到的五种全氟辛烷磺酸（全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）、全氟癸酸（PFDA）和全氟膦酸（PFNA））的血清水平。方法选取2005-2014年参加全国健康与营养调查（NHANES）的4476名年龄≥20岁且PFAS分析结果可用的工人为研究对象。在sas可调用的SUDAAN V11中，使用PFAS子样本权重获得不同行业和职业组的PFAS几何平均血清水平（ng/mL）。结果21个行业中，建筑行业的几何平均PFAS水平（ng/mL）最高（PFOS = 12.61 ng/mL, PFOA = 3.76, PFHxS = 2.10, PFNA = 1.23, PFDA = 0.33），其次是公用事业（PFOS = 12.46）和房地产/租赁/租赁（PFOS = 12.15）。几何平均PFAS水平最低的是私人家庭（PFOS = 6.34, PFOA = 2.12, PFHxS=0.75, PFNA = 0.86, PFDA = 0.25）。在22个职业组中，生命/物理/社会科学职业的几何平均PFAS水平最高（PFOS = 13.19, PFOA = 3.54, PFHxS= 1.69, PFNA = 1.23, PFDA = 0.33），其次是安装/维护/修理职业（PFOS = 12.75）和建筑/采掘职业（PFOS = 12.15）。几何平均PFAS水平最低的职业是个人护理/服务行业（PFOS = 7.25, PFOA = 2.43, PFHxS = 1.07, PFNA = 0.94, PFDA = 0.25）。结论部分行业和职业人群血清PFAS几何平均水平高于其他行业和职业人群。对这些行业和职业的进一步调查可能会更好地了解PFAS的来源和职业暴露程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of industrial medicine 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.90

自引率

5.70%

发文量

108

审稿时长

4-8 weeks

期刊介绍： American Journal of Industrial Medicine considers for publication reports of original research, review articles, instructive case reports, and analyses of policy in the fields of occupational and environmental health and safety. The Journal also accepts commentaries, book reviews and letters of comment and criticism. The goals of the journal are to advance and disseminate knowledge, promote research and foster the prevention of disease and injury. Specific topics of interest include: occupational disease; environmental disease; pesticides; cancer; occupational epidemiology; environmental epidemiology; disease surveillance systems; ergonomics; dust diseases; lead poisoning; neurotoxicology; endocrine disruptors.