The correlation between uric acid to high-density lipoprotein cholesterol ratio and the prevalence of female infertility

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-05-12 DOI:10.1111/jog.16309

Jing Zhe, Dan Zheng

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引用次数: 0

Abstract

Aim

The relationship between uric acid to high-density lipoprotein (HDL) cholesterol ratio (UHR) and female infertility remains unclear. The aim of our study was to explore the correlation between UHR and fertility in US adults.

Methods

Data from the National Health and Nutrition Examination Survey from 2013 to 2018 was analyzed in this study. UHR was considered the independent variable, and female infertility was the dependent variable. Multivariable logistic regression and smooth curve fitting were conducted to evaluate the correlation between UHR and infertility. Subgroup and sensitivity analyses were utilized to assess the stability of the findings.

Results

UHR in transform and female infertility proved to have a positive relationship in logistic regression models, and this relationship remained significant after adjusting for all possible confounding factors (odds ratio [OR] = 1.86, 95% confidence interval: 1.28–2.69, p = 0.001). When UHR was split into four quartile groups, individuals in Tertiles 2, 3, and 4 separately had a 1.84, 1.86, and 2.02 times greater incidence of female infertility than those in Tertile 1. A positive linear relationship between UHR and female infertility incidence was demonstrated using smooth curve fitting. The results of the subgroup analysis revealed consistent correlations and no difference in the UHR index and infertility subgroups (p for interaction tests >0.05).

Conclusion

This national study identified the association between a higher prevalence of female infertility and an elevated UHR. The findings suggested that UHR levels could be useful in predicting the incidence of infertility. The management of UHR should be given more consideration.

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尿酸与高密度脂蛋白胆固醇比值与女性不孕症患病率的关系

目的尿酸与高密度脂蛋白（HDL）胆固醇比值（UHR）与女性不孕症的关系尚不清楚。我们研究的目的是探讨UHR与美国成年人生育能力之间的关系。方法对2013 - 2018年全国健康与营养检查调查数据进行分析。UHR为自变量，女性不育为因变量。采用多变量logistic回归和平滑曲线拟合评价UHR与不孕症的相关性。采用亚组分析和敏感性分析来评估结果的稳定性。结果在logistic回归模型中，UHR与女性不孕症呈正相关，在校正所有可能的混杂因素后，这种关系仍然显著（优势比[OR] = 1.86, 95%可信区间：1.28-2.69,p = 0.001）。当UHR被分成4个四分位数组时，第2、3和4位个体的女性不孕症发生率分别是第1位个体的1.84、1.86和2.02倍。使用平滑曲线拟合证明UHR与女性不孕症发生率呈正线性关系。亚组分析结果显示，UHR指数和不育亚组之间存在一致的相关性，无差异（p为相互作用试验>；0.05）。结论：这项全国性研究确定了女性不孕症患病率较高与UHR升高之间的关联。研究结果表明，UHR水平可用于预测不孕症的发生率。应更多地考虑对UHR的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.