Systematic Review and Meta-Analysis of the Effects of Intestinal Microbiota on Liver Disease Using Mendelian Randomization

Abstract

Background and Objective

The global incidence of liver diseases is on the rise, and targeting gut microbiota has become a new strategy for treating liver diseases. This study provides a comprehensive and objective analysis of the potential protective role of gut microbiota in liver disease, highlighting the need for continued research in this area.

Methods

After literature screening, 24 related articles were included in the study. After article quality and risk of bias assessment, data extraction and data collation were carried out, and then comprehensive analysis was carried out using stata12.0 software.

Results

From the perspective of microbial community, most of the microbial communities at the phylum level are risk factors; from the perspective of the top ten families, the intestinal microbial communities play an obvious harmful role in Primary Biliary Cholangitis.From the perspective of disease, the microbial communities at the genus level mostly have protective effects on Chronic Hepatitis B ,Fatty Liver;and Primary Liver Cancer.

Conclusion

Gut microbiota plays a significant role in the occurrence of liver diseases, and different bacterial levels play different roles in the disease.