Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-05-13 DOI:10.1002/alz.70157

Marissa A. Gogniat, Omair A. Khan, Judy Li, Chorong Park, W. Hudson Robb, Panpan Zhang, Yunyi Sun, Elizabeth E. Moore, Michelle L. Houston, Kimberly R. Pechman, Niranjana Shashikumar, L. Taylor Davis, Dandan Liu, Bennett A. Landman, Keith R. Cole, Corey J. Bolton, Katherine A. Gifford, Timothy J. Hohman, Kelsie Full, Angela L. Jefferson

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引用次数: 0

Abstract

INTRODUCTION

Sedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.

METHODS

Vanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions examined sedentary time in relation to brain structure and cognition. Models were repeated testing for effect modification by apolipoprotein E (APOE) ε4 status.

RESULTS

In cross-sectional models, greater sedentary time related to a smaller AD-neuroimaging signature (β = -0.0001, p = 0.01) and worse episodic memory (β = -0.001, p = 0.003). Associations differed by APOE-ε4 status. In longitudinal models, greater sedentary time related to faster hippocampal volume reductions (β = -0.1, p = 0.008) and declines in naming (β = -0.001, p = 0.03) and processing speed (β = -0.003, p = 0.02; β = 0.01, p = 0.01).

DISCUSSION

Results support the importance of reducing sedentary time, particularly among aging adults at genetic risk for AD.

Highlights

Greater sedentary behavior is related to neurodegeneration and worse cognition.
Associations differed by APOE-ε4 carrier status in cross-sectional models.
Sedentary behavior is an independent risk factor for Alzheimer's disease.

Abstract Image

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在长达7年的时间里，尽管老年人的身体活动水平很高，但久坐行为的增加与神经退化和认知能力下降有关

久坐行为可能是阿尔茨海默病（AD）的一个可改变的危险因素。我们研究了久坐行为与老年人纵向大脑结构和认知变化之间的关系。方法范德比尔特记忆与衰老项目参与者（n = 404）在7年的时间里完成了活动摄影（7天）、神经心理学评估和3T脑MRI。横截面和纵向线性回归研究了久坐时间与大脑结构和认知的关系。通过载脂蛋白E (APOE) ε4状态对模型进行反复试验。结果：在横断面模型中，久坐时间越长，ad神经成像特征越小（β = -0.0001, p = 0.01），情景记忆越差（β = -0.001, p = 0.003）。不同APOE-ε4状态的相关性不同。在纵向模型中，久坐时间越长，海马体积减少越快（β = -0.1, p = 0.008），命名能力（β = -0.001, p = 0.03）和处理速度（β = -0.003, p = 0.02）下降越快；β = 0.01, p = 0.01)。讨论：研究结果支持减少久坐时间的重要性，特别是对于有AD遗传风险的老年人。久坐行为与神经退化和认知能力下降有关。在横截面模型中，不同APOE-ε4载体状态的相关性不同。久坐行为是阿尔茨海默病的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.