Effect of Probucol and Atorvastatin Treatment on the Self-Care Ability of Acute Cerebral Infarction Patients: A Randomized Clinical Trial Study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-05-13 DOI:10.1002/brb3.70552

Ning Yu, Yajing Li, Xue Han, Yuan Sun, Yun Li, Yanjun Gao, Xiaoxuan Zhang

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引用次数: 0

Abstract

Background

To investigate the effect of probucol and atorvastatin on self-care ability in patients with acute cerebral infarction (ACI).

Methods

Eighty-one patients with ACI admitted from November 2020 to May 2021 were divided into a combination treatment group (n = 40) and an atorvastatin group (n = 41). The atorvastatin group was given atorvastatin on the basis of conventional treatment, and the combination treatment group was treated with probucol and atorvastatin on the control basis. Self-care ability and blood lipid levels were assessed at baseline and 6 months after treatment using the Barthel Index (BI) and biochemical tests. The study also included MRI scans to evaluate infarct volume and monitored relevant clinical indicators.

Results

The baseline data of both groups were consistent and comparable. After six months, both groups showed improved self-care ability, with the combined treatment group exhibiting a more significant improvement (P < 0.05). The combination treatment group also demonstrated a significant reduction in total cholesterol (TCH) and low-density lipoprotein (LDL) levels compared to the atorvastatin group (P < 0.05). The factors influencing self-care ability included history of cerebrovascular disease, treatment modality, and LDL levels.

Conclusion

Probucol combined with atorvastatin significantly enhances self-care ability and improves blood lipid levels in patients with ACI. This combination therapy is safe, feasible, and recommended for clinical application to reduce cognitive decline and improve quality of life in these patients.

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普罗布考和阿托伐他汀治疗对急性脑梗死患者自我护理能力的影响：一项随机临床试验研究

背景探讨普罗布考和阿托伐他汀对急性脑梗死（ACI）患者自我护理能力的影响。方法将2020年11月至2021年5月收治的81例ACI患者分为联合治疗组（n = 40）和阿托伐他汀组（n = 41）。阿托伐他汀组在常规治疗的基础上给予阿托伐他汀治疗，联合治疗组在对照基础上给予普罗布考和阿托伐他汀治疗。在治疗前和治疗后6个月，采用Barthel指数（BI）和生化试验评估自我护理能力和血脂水平。该研究还包括MRI扫描以评估梗死面积并监测相关临床指标。结果两组基线数据一致，具有可比性。6个月后，两组患者的自理能力均有所改善，其中联合治疗组改善更为显著(P <；0.05)。与阿托伐他汀组相比，联合治疗组总胆固醇（TCH）和低密度脂蛋白（LDL）水平也显著降低(P <；0.05)。影响自理能力的因素包括脑血管病史、治疗方式、低密度脂蛋白水平。结论普罗布考联合阿托伐他汀可显著提高ACI患者的生活自理能力，改善患者血脂水平。这种联合治疗是安全、可行的，推荐临床应用，以减少这些患者的认知能力下降，提高生活质量。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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