Association Between Abnormal Plasma Lipid Metabolism and Psychological Characteristics in Adolescents With Major Depressive Disorder

IF 3.3 2区医学 Q1 PSYCHIATRY

Depression and Anxiety Pub Date : 2025-05-12 DOI:10.1155/da/5564796

Yuxin Wang, Hui Chen, Jinfeng Wang, Shurui Chen, Jiali Liu, Xianliang Chen, Sihong Li, Huajia Tang, Jiawei Zhou, Yanyue Ye, Yusheng Tian, Xiaoping Wang, Jiansong Zhou

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引用次数: 0

Abstract

Background: Major depressive disorder (MDD) in adolescents is a significant global public health issue, yet its pathophysiological mechanism remains unclear. Although changes in lipid metabolites have been observed in people with MDD, most relevant studies focus on adults, with limited research on adolescents. Furthermore, little is known about how interactions between metabolites and psychosocial factors contribute to MDD among adolescents. This study aimed to explore the relationship between lipid metabolism and psychological characteristics in adolescents with MDD to provide insights into its biological mechanisms.

Methods: A cross-sectional study was conducted on 40 adolescents with MDD patients and 20 healthy controls (HCs). Plasma samples were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for targeted lipidomics. Spearman analysis was employed to examine the correlation between differentially expressed lipids and the psychological characteristics of participants.

Results: We identified significant differences in 37 lipid species, including glycerophospholipids (GPs), glycerolipids (GLs), and sphingolipids (SPs), with a specific focus on lysophosphatidylcholine (LPC; 18:0), which demonstrated high diagnostic potential (area under the curve (AUC) = 0.886). Pathway analysis revealed significant disturbances in GP metabolism. Spearman correlation analysis showed that most differential lipid metabolites were negatively correlated with scores of depressive symptoms, childhood maltreatment (CM), extraversion, and neuroticism, while positively correlated with scores of psychoticism and positive coping in adolescents with MDD.

Conclusions: The study showed that adolescents with MDD presented a significantly differentiated profile of plasma lipidomics compared to HCs. These findings may contribute to a better understanding of the role of lipid metabolism in adolescent MDD.

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青少年重度抑郁症患者血浆脂质代谢异常与心理特征的关系

背景：青少年重度抑郁障碍（MDD）是一个重大的全球公共卫生问题，但其病理生理机制尚不清楚。虽然在重度抑郁症患者中观察到脂质代谢物的变化，但大多数相关研究都集中在成年人身上，对青少年的研究有限。此外，代谢物和社会心理因素之间的相互作用如何影响青少年的重度抑郁症，我们所知甚少。本研究旨在探讨青少年重度抑郁症患者的脂质代谢与心理特征之间的关系，为其生物学机制提供依据。方法：对40名青少年重度抑郁症患者和20名健康对照者进行横断面研究。血浆样品采用超高效液相色谱-串联质谱（UPLC-MS/MS）进行靶向脂质组学分析。采用Spearman分析来检验差异表达的脂质与参与者心理特征之间的相关性。结果：我们确定了37种脂类的显著差异，包括甘油磷脂（GPs）、甘油脂（GLs）和鞘脂（SPs），特别关注溶血磷脂酰胆碱(LPC；18:0)，具有较高的诊断潜力（曲线下面积(AUC) = 0.886）。通路分析显示GP代谢明显紊乱。Spearman相关分析显示，大多数差异脂质代谢物与抑郁症状、童年虐待、外向性和神经质得分呈负相关，而与精神质和积极应对得分呈正相关。结论：该研究表明，与hc相比，MDD青少年的血浆脂质组学表现出显著差异。这些发现可能有助于更好地理解脂质代谢在青少年重度抑郁症中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Depression and Anxiety 医学-精神病学

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.