Anhedonia Symptoms and High Sensitivity C-Reactive Protein (hs-CRP) Several Years Postpartum

Abstract

Problem

Despite adverse maternal and child consequences, postpartum depression 1.6–3 years post-delivery remains poorly understood, particularly anhedonia (lack of interest or pleasure), which can harm maternal–child relationships. Understanding the biological pathways underlying maternal depression and identifying biomarkers that contribute to its diverse symptoms is essential.

Method of Study

This study investigated relations between hs-CRP levels and symptoms of depression in mothers 1.6–3 years post-delivery (N = 49), and examined associations between specific symptoms of depression and hs-CRP.

Results

Clinically elevated symptoms of depression were present in 14.2%. Symptoms of depression were not significantly associated with maternal characteristics but were associated with having a Neonatal Intensive Care Unit (NICU) admission, maternal age, and a recent history of mental illness. Greater depression and anhedonia symptoms were associated with greater levels of hs-CRP (r = 0.308, p < 0.05; r = 0.314, p < 0.05, respectively). Adjusting for maternal age, BMI, months postpartum, and pregnancy status, elevated depression (not anhedonia) remained associated with higher levels of hs-CRP (β = 0.342, p < 0.05).

Conclusions

Women with clinically elevated symptoms of depression had significantly higher levels of hs-CRP, suggesting that it may be an important inflammatory biomarker for symptoms of depression 1–3 years post-delivery and helps identify those in need of follow up.