High Burden of Dengue and Chikungunya Virus in Paraguay: Seroprevalence Findings From Blood Donors

IF 6.8 3区 医学 Q1 VIROLOGY
Diego M. Flichman, Nelson Marquez, Matías Javier Pereson, Victor A. Sánchez S, Andrea S. Gómez de la Fuente, Cecilia González, José Martín Lema, Sonia L. Espíndola, Graciela M. Carballo, Alfredo P. Martínez, Patricia Baré, Federico A. Di Lello
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引用次数: 0

Abstract

The rise of reemerging pathogens such as DENV and CHIKV presents a major public health threat. With half the global population at risk, Paraguay experiences particularly high infection rates. Despite this, data on the seroprevalence of these viruses in this country is lacking. This study aims to assess the seroprevalence of anti-DENV IgG and anti-CHIKV IgG among blood donors in Paraguay. Serum samples from 546 blood donors across seven regional districts and Asunción were collected from March to May 2023. Participants filled out a questionnaire and underwent eligibility screening. Serum samples were tested for anti-DENV IgG and anti-CHIKV IgG antibodies using immunoassays. Data were analyzed using IBM SPSS version 23.0. The median (IQR) age of donors was 34 (26–44), and 47.1% were female. Anti-DENV IgG prevalence was 87.7%, ranging from 73.7% to 100% by location, with an age-related association. Donors aged 18 to 25 had a 79.2% seroprevalence, while those over 46 had the highest at 91.5% (p = 0.010). Anti-CHIKV IgG prevalence was 37.2%, with men showing a seroprevalence nearly 10% higher than women, but no significant age-related differences were observed. Regional variation in CHIKV seroprevalence was not significant. In conclusion, this study suggests a high seroprevalence of both DENV and CHIKV in Paraguayan blood donors. The high DENV seroprevalence reflects the impact of past outbreaks, while the notable CHIKV prevalence underscores the effects of recent outbreaks. Continuous surveillance, improved diagnostics, and effective vector control measures are essential to mitigate these arboviruses' impact in Paraguay.

巴拉圭登革热和基孔肯雅病毒高负担:献血者血清阳性率调查结果
DENV和CHIKV等重新出现的病原体的增加构成了重大的公共卫生威胁。巴拉圭的感染率特别高,占全球人口的一半。尽管如此,这个国家缺乏这些病毒的血清流行率的数据。本研究旨在评估巴拉圭献血者中抗denv IgG和抗chikv IgG的血清阳性率。从2023年3月至5月收集了7个大区和Asunción的546名献血者的血清样本。参与者填写了一份调查问卷,并进行了资格筛选。用免疫分析法检测血清样本抗denv IgG和抗chikv IgG抗体。数据分析采用IBM SPSS 23.0。献血者的中位年龄(IQR)为34岁(26-44岁),女性占47.1%。抗denv IgG患病率为87.7%,不同地区的患病率从73.7%到100%不等,与年龄相关。18 ~ 25岁的献血者血清阳性率为79.2%,46岁以上的献血者血清阳性率最高,为91.5% (p = 0.010)。抗- chikv IgG流行率为37.2%,男性血清阳性率比女性高近10%,但未观察到明显的年龄相关差异。猪流感病毒血清阳性率地区差异不显著。总之,这项研究表明巴拉圭献血者中DENV和CHIKV的血清阳性率都很高。DENV的高血清阳性率反映了过去疫情的影响,而CHIKV的显著流行则强调了最近疫情的影响。持续监测、改进诊断和有效的病媒控制措施对于减轻虫媒病毒在巴拉圭的影响至关重要。
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来源期刊
Journal of Medical Virology
Journal of Medical Virology 医学-病毒学
CiteScore
23.20
自引率
2.40%
发文量
777
审稿时长
1 months
期刊介绍: The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.
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