A crystalline Sm(III)-containing antimonotungstate with efficient catalytic activity in three-component reaction for isoindolinones synthesis

IF 9.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Rare Metals Pub Date : 2025-03-07 DOI:10.1007/s12598-024-03179-6

Hao-Qi Liu, Jia-Wei Cao, Wei Tang, Zhou-Fu Lin, Ke Li, Wei-Jian Xu, Zhi-Bin Zhang, Yu-Feng Liu, Guo-Ping Yang

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引用次数: 0

Abstract

The development of the three-component catalytic system for constructing isoindolinones from simple feedstocks is both significant and challenging. In this study, a unique tartrate-linked dimeric samarium-antimonotungstate [Sm₂(H₂O)₆(tar)(Sb₂W₂₁O₇₂)]₂²⁰⁻ (Sm₄tar₂, H₄tar = tartaric acid) was synthesized via a one-step method at room temperature using an acetate buffer solution. The dimeric polyanion of Sm₄tar₂ shows a centrosymmetric structure with a parallelogram-like arrangement and comprises two enantiomeric {Sm₂(H₂O)₆(Sb₂W₂₁O₇₂)} moieties connected by two enantiomeric tar ligands. Sm₄tar₂ demonstrates efficient catalytic activity in the three-component reaction involving 2-acylbenzoic acids, primary amines, and phosphine oxides to form 3,3-disubstituted isoindolinones. The advantages of this catalytic system include simple feedstocks, green and reusable catalyst, and operational simplicity with water as the sole by-product. This finding enables an effective molecular fragment assembly strategy for synthesizing isoindolinone drug precursor skeletons.

Graphical abstract

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含Sm（III）的反单钨酸盐晶体在三组分反应合成异吲哚酮中具有高效的催化活性

从简单原料合成异吲哚酮的三组分催化体系的发展具有重要的意义和挑战性。在本研究中，采用醋酸缓冲液，在室温下一步合成了一种独特的酒石酸连接二聚体钐-反单钨酸盐[Sm2(H2O)6(tar)(Sb2W21O72)]220−（Sm4tar2, H4tar =酒石酸）。Sm4tar2的二聚阴离子呈平行四边形排列的中心对称结构，由两个对映体{Sm2(H2O)6(Sb2W21O72)}组成，由两个对映体配体连接。Sm4tar2在2-酰基苯甲酸、伯胺和氧化膦生成3,3-二取代异吲哚酮的三组分反应中表现出高效的催化活性。该催化系统的优点包括原料简单，催化剂绿色可重复使用，操作简单，水是唯一的副产品。这一发现为合成异吲哚酮药物前体骨架提供了一种有效的分子片段组装策略。图形抽象

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来源期刊

Rare Metals 工程技术-材料科学：综合

CiteScore

12.10

自引率

12.50%

发文量

2919

审稿时长

2.7 months

期刊介绍： Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.