{"title":"Relationship of grain size to the physicochemical properties and osteogenesis in magnesium–zinc–calcium alloys for bone implants","authors":"Shu-Quan Zhang, Jiang-Tao Feng, Zhi-Gang Cui, Ai-Min Zhang, Chao-Kun Tang, Ran Pang, Xing-Long Zhang, Chen-Guang Li, Feng-Xin Zhou, Feng Xue, Hao Wang, Jing-Yu Zhang, Qing-Hong Song, Min-Fang Chen, Bin Yao, Shao-Yuan Lyu, Bao-Shan Xu","doi":"10.1007/s12598-024-03160-3","DOIUrl":null,"url":null,"abstract":"<p>Magnesium–zinc–calcium alloy has emerged as a key focus in the field of medical degradable materials due to its excellent biodegradability and osteoconductive properties. Grain size is crucial for the physicochemical and biological properties of Mg–Zn–Ca alloy, but it has not been clearly elucidated yet. In this research, Mg-1Zn-0.2Ca-1.0MgO with different grain sizes were prepared to investigate the effect of grain size on the physicochemical properties, corrosion resistance, and osteogenesis. The results indicate that grain refinement improves the mechanical properties and enhances the corrosion resistance of the alloy. The bone surface area to bone volume ratio, bone surface area to tissue volume ratio, and bone volume fraction of the 0.6–0.8 μm group show significantly better performance compared to the 2–3 μm group and 5–6 μm group, indicating that grain refinement can promote the osseointegration between alloy and natural bone. This may be achieved by enhancing the metabolic intensity of alanine, aspartate, glutamate, serine, and glycine around the implant. This work illustrates the effect of grain size on the osseointegration of bone implants and provides a reference for optimizing the properties of bone implant alloys.</p>","PeriodicalId":749,"journal":{"name":"Rare Metals","volume":"44 6","pages":"4191 - 4207"},"PeriodicalIF":9.6000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rare Metals","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s12598-024-03160-3","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Magnesium–zinc–calcium alloy has emerged as a key focus in the field of medical degradable materials due to its excellent biodegradability and osteoconductive properties. Grain size is crucial for the physicochemical and biological properties of Mg–Zn–Ca alloy, but it has not been clearly elucidated yet. In this research, Mg-1Zn-0.2Ca-1.0MgO with different grain sizes were prepared to investigate the effect of grain size on the physicochemical properties, corrosion resistance, and osteogenesis. The results indicate that grain refinement improves the mechanical properties and enhances the corrosion resistance of the alloy. The bone surface area to bone volume ratio, bone surface area to tissue volume ratio, and bone volume fraction of the 0.6–0.8 μm group show significantly better performance compared to the 2–3 μm group and 5–6 μm group, indicating that grain refinement can promote the osseointegration between alloy and natural bone. This may be achieved by enhancing the metabolic intensity of alanine, aspartate, glutamate, serine, and glycine around the implant. This work illustrates the effect of grain size on the osseointegration of bone implants and provides a reference for optimizing the properties of bone implant alloys.
期刊介绍:
Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.