Relationship of grain size to the physicochemical properties and osteogenesis in magnesium–zinc–calcium alloys for bone implants

IF 9.6 1区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Shu-Quan Zhang, Jiang-Tao Feng, Zhi-Gang Cui, Ai-Min Zhang, Chao-Kun Tang, Ran Pang, Xing-Long Zhang, Chen-Guang Li, Feng-Xin Zhou, Feng Xue, Hao Wang, Jing-Yu Zhang, Qing-Hong Song, Min-Fang Chen, Bin Yao, Shao-Yuan Lyu, Bao-Shan Xu
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Abstract

Magnesium–zinc–calcium alloy has emerged as a key focus in the field of medical degradable materials due to its excellent biodegradability and osteoconductive properties. Grain size is crucial for the physicochemical and biological properties of Mg–Zn–Ca alloy, but it has not been clearly elucidated yet. In this research, Mg-1Zn-0.2Ca-1.0MgO with different grain sizes were prepared to investigate the effect of grain size on the physicochemical properties, corrosion resistance, and osteogenesis. The results indicate that grain refinement improves the mechanical properties and enhances the corrosion resistance of the alloy. The bone surface area to bone volume ratio, bone surface area to tissue volume ratio, and bone volume fraction of the 0.6–0.8 μm group show significantly better performance compared to the 2–3 μm group and 5–6 μm group, indicating that grain refinement can promote the osseointegration between alloy and natural bone. This may be achieved by enhancing the metabolic intensity of alanine, aspartate, glutamate, serine, and glycine around the implant. This work illustrates the effect of grain size on the osseointegration of bone implants and provides a reference for optimizing the properties of bone implant alloys.

骨植入用镁锌钙合金晶粒尺寸与理化性质及成骨的关系
镁锌钙合金因其优异的生物降解性和骨导电性而成为医用可降解材料领域的研究热点。晶粒尺寸对Mg-Zn-Ca合金的物理化学和生物性能至关重要,但目前还没有明确的认识。本研究制备了不同晶粒尺寸的Mg-1Zn-0.2Ca-1.0MgO,研究晶粒尺寸对其理化性能、耐蚀性和成骨性的影响。结果表明,晶粒细化改善了合金的力学性能,提高了合金的耐蚀性。与2-3 μm组和5-6 μm组相比,0.6 ~ 0.8 μm组的骨表面积与骨体积比、骨表面积与组织体积比和骨体积分数表现出明显更好的性能,说明晶粒细化能够促进合金与天然骨之间的骨整合。这可以通过增强种植体周围丙氨酸、天冬氨酸、谷氨酸、丝氨酸和甘氨酸的代谢强度来实现。本研究阐明了晶粒尺寸对骨种植体骨整合的影响,为优化骨种植体合金的性能提供了参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rare Metals
Rare Metals 工程技术-材料科学:综合
CiteScore
12.10
自引率
12.50%
发文量
2919
审稿时长
2.7 months
期刊介绍: Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.
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