The impact of platelets and antiplatelets medications on immune mediation

Q3 Medicine

JVS-vascular science Pub Date : 2025-01-01 DOI:10.1016/j.jvssci.2024.100278

Leela Morena MD , Isabella Ferlini Cieri MD , Daniel Marconi Mendes PhD , Sasha P. Suarez Ferreira MD , Shiv Patel BS , Samir Ghandour MD , Maria Fernanda Andrade BS , Mohit Manchella BS , Adriana A. Rodriguez MD , Henry Davies MBBS, MD, MRSC , Shruti Sharma PhD , Anahita Dua MD, MS, MBA

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Abstract

Objective

To investigate the mechanisms through which platelets and antiplatelet therapies modulate the immune response and propose directions for future research in this field, with a particular emphasis on their impact on treatment efficacy and surgical outcomes.

Methods

A comprehensive review of recent studies investigating the role of platelets in immune modulation, specifically highlighting their involvement in pathogen recognition, leukocyte recruitment, and lymphocyte activation. Additionally, the review evaluates the impact of antiplatelet therapies, such as aspirin, P2Y12 inhibitors, and glycoprotein IIb/IIIa inhibitors, on immune responses.

Results

Recent studies have emphasized the critical role of platelets in immune-driven applications, namely, atherosclerosis, cancer, viral infections, and sepsis. These studies also suggest that antiplatelet therapies may alter immune responses. However, the precise mechanisms through which platelets and antiplatelet drugs influence immune responses, as well as their effects on post-treatment and surgical outcomes, are not yet fully elucidated.

Conclusions

Recent studies highlight the important role of platelets in immune processes, such as in atherosclerosis, cancer, viral infections, and sepsis, and suggest that antiplatelet therapies can influence immune responses. However, the exact mechanisms by which platelets and antiplatelet drugs modulate these responses remain unclear. This area presents valuable opportunities for future research to uncover these mechanisms, which could lead to novel therapeutic strategies and better clinical outcomes for patients.

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血小板和抗血小板药物对免疫中介的影响

目的探讨血小板和抗血小板治疗对免疫反应的调节机制，并提出该领域未来的研究方向，重点研究血小板和抗血小板治疗对治疗效果和手术结果的影响。方法对近期研究血小板在免疫调节中的作用进行综述，特别强调了血小板在病原体识别、白细胞募集和淋巴细胞活化中的作用。此外，本综述还评估了抗血小板疗法（如阿司匹林、P2Y12抑制剂和糖蛋白IIb/IIIa抑制剂）对免疫反应的影响。最近的研究强调了血小板在免疫驱动应用中的关键作用，即动脉粥样硬化、癌症、病毒感染和败血症。这些研究还表明抗血小板治疗可能改变免疫反应。然而，血小板和抗血小板药物影响免疫反应的确切机制，以及它们对治疗后和手术结果的影响，尚未完全阐明。最近的研究强调了血小板在免疫过程中的重要作用，如动脉粥样硬化、癌症、病毒感染和败血症，并表明抗血小板治疗可以影响免疫反应。然而，血小板和抗血小板药物调节这些反应的确切机制尚不清楚。这一领域为未来研究揭示这些机制提供了宝贵的机会，这可能会导致新的治疗策略和更好的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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