Functionalization of 5-hydroxyindole-based i-melanin pigment for hair dyeing and UV-protective applications

IF 7.3 2区材料科学 Q1 CHEMISTRY, APPLIED

Progress in Organic Coatings Pub Date : 2025-05-12 DOI:10.1016/j.porgcoat.2025.109368

Chan-Seo Yeo , Jongyun Choi , Hee-Jung Kim , Joo Hee Chung , HyunA Park , Jong-Bok Seo , Ji Chul Jung , Wonjong Jung , Kwon-Young Choi

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Abstract

In this study, 5-hydroxyindole-based i-melanin was biosynthesized through enzymatic reactions catalyzed by flavin monooxygenase (FMO) and sequential MelC tyrosinase. The monomer underwent intracellular random polymerization, resulting in a novel symmetric melanin. The synthesized i-melanin exhibited a significantly darker black coloration compared to conventional melanin and demonstrated enhanced biological activities, including antioxidant and antibacterial properties. The physical and biological characteristics of i-melanin were analyzed using UV/Vis spectroscopy, ABTS assays, and growth inhibition studies. Notably, i-melanin displayed antifungal activity against Candida albicans. For functional applications, i-melanin was formulated as a hair dye and incorporated into a UV-protection cream through complexation with ZnO. Both formulations exhibited excellent dyeing efficacy and UV-blocking performance. Given the high production yield of i-melanin, its scalability for industrial applications appears promising. These findings suggest that this novel melanin has potential for integration into various functional products in the future.

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5-羟基吲哚基i-黑色素的功能化及其在染发和防紫外线中的应用

本研究以黄素单加氧酶（flavin monooxygenase， FMO）和序列MelC酪氨酸酶为催化反应，合成了5-羟基吲哚基i-melanin。该单体在细胞内进行了随机聚合，产生了一种新的对称黑色素。与传统黑色素相比，合成的i-黑色素呈现出明显更深的黑色，并显示出增强的生物活性，包括抗氧化和抗菌性能。采用紫外/可见光谱法、ABTS法和生长抑制实验分析i-melanin的物理和生物学特性。值得注意的是，i-黑色素对白色念珠菌显示出抗真菌活性。在功能性应用方面，i-黑色素被配制成一种染发剂，并通过与氧化锌络合而加入到防紫外线乳霜中。两种配方均表现出优异的染色效果和防紫外线性能。鉴于i-黑色素的高产量，其工业应用的可扩展性似乎很有前景。这些发现表明，这种新型黑色素在未来有可能整合到各种功能性产品中。

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来源期刊

Progress in Organic Coatings 工程技术-材料科学：膜

CiteScore

11.40

自引率

15.20%

发文量

577

审稿时长

48 days

期刊介绍： The aim of this international journal is to analyse and publicise the progress and current state of knowledge in the field of organic coatings and related materials. The Editors and the Editorial Board members will solicit both review and research papers from academic and industrial scientists who are actively engaged in research and development or, in the case of review papers, have extensive experience in the subject to be reviewed. Unsolicited manuscripts will be accepted if they meet the journal''s requirements. The journal publishes papers dealing with such subjects as: • Chemical, physical and technological properties of organic coatings and related materials • Problems and methods of preparation, manufacture and application of these materials • Performance, testing and analysis.