A novel 2H-MoS2/MoO3/1T-MoS2 ternary heterojunction SERS sensor with high carrier concentration and mobility for highly sensitive and highly selective detection of bilirubin in urine

IF 8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Sensors and Actuators B: Chemical Pub Date : 2025-05-12 DOI:10.1016/j.snb.2025.137961

Yimin Tang , Weijie Di , Rui Wang , Huizhu Zhang , Libin Yang , Xin Jiang , Xiuwen Wang , Bing Zhao

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Abstract

Constructing a semiconductor heterojunction with high carrier concentration and mobility is an effective strategy to boost the surface-enhanced Raman scattering (SERS) performance of semiconductor. Here, a novel ternary molybdenum-based compound heterojunction 2H-MoS₂/MoO₃/1T-MoS₂ was developed as an excellent semiconducting SERS substrate for ultrasensitive detection of bilirubin in urine. Theoretical calculation and experimental results prove the contribution of charge transfer mechanism to SERS enhancement. The high carrier concentration in the substrate and the high electron mobility induced by the heterostructure are together responsible for its huge SERS enhancement effect. The substrate has a limit of detection (LOD) of 1.05 × 10⁻¹⁰ M and a SERS enhancement factor (EF) of 1.48 × 10⁹ for methylene blue probe. More meaningfully, the developed heterojunction substrate can achieve an ultrasensitive and high-selectivity detection for bilirubin in human urine, and the LOD is as low as 9.94 × 10⁻⁹ M.

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一种新型的高载流子浓度、高迁移率的2H-MoS2/MoO3/1T-MoS2三元异质结SERS传感器，用于高灵敏度、高选择性检测尿中胆红素

构建具有高载流子浓度和迁移率的半导体异质结是提高半导体表面增强拉曼散射（SERS）性能的有效策略。本文开发了一种新型的三元钼基化合物异质结2H-MoS2/MoO3/1T-MoS2，作为一种优异的半导体SERS底物，用于超灵敏检测尿液中的胆红素。理论计算和实验结果证明了电荷转移机制对SERS增强的贡献。衬底中高载流子浓度和异质结构诱导的高电子迁移率共同导致了其巨大的SERS增强效应。亚甲基蓝探针的检出限（LOD）为1.05 × 10−10 M， SERS增强因子（EF）为1.48 × 109。更有意义的是，所开发的异质结底物可以实现对人尿中胆红素的超灵敏、高选择性检测，LOD低至9.94 × 10−9 M。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators B: Chemical 工程技术-电化学

CiteScore

14.60

自引率

11.90%

发文量

1776

审稿时长

3.2 months

期刊介绍： Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.