A longitudinal functional connectivity study of bipolar Disorder: from the view of default mode network and its association with gene expression

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-05-07 DOI:10.1016/j.jpsychires.2025.05.019

Xuhan Cui , Yiding Han , Haohao Yan , Chunguo Zhang , Xiaoling Li , Jiaquan Liang , Chaohua Tang , Weibin Wu , Wen Deng , Guojun Xie , Wenbin Guo

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引用次数: 0

Abstract

Objective

Abnormal functions involving brain regions within the default mode network (DMN) have been reported in bipolar disorder (BD). However, most previous studies were cross-sectional. Therefore, a longitudinal study was conducted to observe the change trajectory of symptoms and functional connectivity (FC) of DMN in BD patients. Imaging transcriptomics is used for finding spatially transcriptional correlation of FC changes.

Methods

Eighty-two BD patients (43 patients finished the follow-up after 3-month medication treatment) and matched 88 healthy controls were included to perform seed-based FC analysis. The correlation between FC alteration and clinical symptoms was explored with multiple regression analysis. Utilizing imaging transcriptomics, genes from the Allen Human Brain Atlas associated with abnormal imaging phenotypes were obtained by spatial Spearman correlation analysis.

Results

BD patients exhibited increased FC between the DMN and the orbitofrontal cortex (OFC), left cerebellar Crus II/VIIb, right inferior frontal gyrus, and bilateral anterior cingulate cortex. After treatment, elevated FC of DMN-OFC tended to normalize, while decreased FC within the inferior parietal gyrus (IPG) was observed. Two FC alterations of left IPG were positively associated with the Stroop Color-Word Test (p = 0.0014, 0.0019 respectively). Enrichment analysis suggested association genes were involved in ribosomal function, membrane transport, and enzymatic activity.

Conclusion

The findings further suggest that FC of DMN may relate to symptomatic changes and therapeutic mechanisms of BD. Imaging transcriptomics provides a new perspective for researching genetic factors of BD. However, the small sample and single center of this study may impact the representativeness of the results.

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双相情感障碍的纵向功能连通性研究：基于默认模式网络及其与基因表达的关联

目的双相情感障碍（BD）中涉及默认模式网络（DMN）脑区域的异常功能已被报道。然而，大多数先前的研究都是横断面的。因此，我们进行了一项纵向研究，观察BD患者DMN症状和功能连通性（FC）的变化轨迹。成像转录组学用于发现FC变化的空间转录相关性。方法选取82例BD患者（其中43例在药物治疗3个月后完成随访）和匹配的88例健康对照，进行基于种子的FC分析。采用多元回归分析探讨FC改变与临床症状的相关性。利用成像转录组学，通过空间Spearman相关分析获得Allen人脑图谱中与异常成像表型相关的基因。结果bd患者DMN与眶额皮质（OFC）、左侧小脑II/ vib小腿、右侧额下回和双侧前扣带皮层之间的FC增加。治疗后，DMN-OFC的FC升高趋于正常化，而顶叶下回（IPG） FC下降。左IPG的两个FC改变与Stroop颜色-单词测试呈正相关（p分别= 0.0014,0.0019）。富集分析表明相关基因参与核糖体功能、膜转运和酶活性。结论DMN的FC可能与双相障碍的症状改变及治疗机制有关，成像转录组学为研究双相障碍的遗传因素提供了新的视角，但本研究样本量小、中心单一，可能影响结果的代表性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;