Autogenic uterus transplantation in goats: Animal model experience in Taiwan

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-05-01 DOI:10.1016/j.tjog.2025.04.002

Cherry Yin-Yi Chang , Chien-Chu Huang , Shih-Te Chuang , Jui-Chun Hsieh , Ping-Chun Li , Yu-Wen Sung , Kin-Shing Poon , Hsiu-Yu Lai , Wu-Chou Lin

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引用次数: 0

Abstract

Objective

Uterus transplantation (UTx) is a solution for women with uterine infertility. In this study, we aimed to explore surgical methods for autogenic UTx in a goat model and assess the function of the uterus and the surgical outcome.

Materials and methods

Female goats (n = 4) underwent autologous transplantation of the uterus via laparotomy. The pelvic tissue was carefully dissected and exposed. The uterine arteries were dissected to the entire internal iliac artery, and the ovarian veins were also dissected to the point where they crossed over the ureter. Back-table preparation was performed when the graft was removed. After the end-to-side anastomosis of the blood vessels was completed, vaginal anastomosis was performed. The surgery time, ischemia time, and surgical outcomes were recorded. After surgery, the viability of the uterus was examined via hysteroscopy, and an endometrial biopsy was performed.

Results

Overall, the survival rate of the animals was 75 % (one goat died because of an allergic reaction to the anesthetic medication one day after the operation). Among the three surviving goats, two resumed ovarian cyclicity. Adhesions in the cavity were observed in one goat.

Conclusion

The goat UTx model is a good model for performing this procedure. Our results revealed that uterine function resumed in the majority of the animals, although pregnancy could not be confirmed.

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山羊自体子宫移植：台湾动物模型经验

目的子宫移植是治疗子宫不孕症的一种有效方法。在本研究中，我们旨在探讨山羊自体UTx模型的手术方法，并评估子宫功能和手术结果。材料与方法母山羊（n = 4）经剖腹手术行自体子宫移植。仔细解剖并暴露骨盆组织。剖开子宫动脉至整个髂内动脉，剖开卵巢静脉至与输尿管相交处。移植物移除后进行背台准备。血管端侧吻合完成后，行阴道吻合。记录手术时间、缺血时间及手术结果。手术后，通过宫腔镜检查子宫活力，并进行子宫内膜活检。结果全组动物成活率为75%（1只山羊术后1天因对麻醉药物过敏死亡）。幸存的3只山羊中，有2只恢复了卵巢周期。其中1只山羊出现腔内粘连。结论山羊UTx模型是一种较好的手术模型。我们的研究结果显示，大多数动物的子宫功能恢复，尽管不能证实怀孕。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Taiwanese Journal of Obstetrics & Gynecology OBSTETRICS & GYNECOLOGY-

CiteScore

3.60

自引率

23.80%

发文量

207

审稿时长

4-8 weeks

期刊介绍： Taiwanese Journal of Obstetrics and Gynecology is a peer-reviewed journal and open access publishing editorials, reviews, original articles, short communications, case reports, research letters, correspondence and letters to the editor in the field of obstetrics and gynecology. The aims of the journal are to: 1.Publish cutting-edge, innovative and topical research that addresses screening, diagnosis, management and care in women''s health 2.Deliver evidence-based information 3.Promote the sharing of clinical experience 4.Address women-related health promotion The journal provides comprehensive coverage of topics in obstetrics & gynecology and women''s health including maternal-fetal medicine, reproductive endocrinology/infertility, and gynecologic oncology. Taiwan Association of Obstetrics and Gynecology.