A unique case of extra-cerebral diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters

Q4 Medicine

Radiology Case Reports Pub Date : 2025-05-12 DOI:10.1016/j.radcr.2025.04.067

Wu Maurice MD , Naderian Ashkun MD , Iyengar Krishnan MBBS, MD, DNB, FRCPA , Coulthard Alan FRCSEd, FRCR, FRANZCR, GAICD , Jeffree Rosalind MBBS, MSc, FRACS, MHE

{"title":"A unique case of extra-cerebral diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters","authors":"Wu Maurice MD , Naderian Ashkun MD , Iyengar Krishnan MBBS, MD, DNB, FRCPA , Coulthard Alan FRCSEd, FRCR, FRANZCR, GAICD , Jeffree Rosalind MBBS, MSc, FRACS, MHE","doi":"10.1016/j.radcr.2025.04.067","DOIUrl":null,"url":null,"abstract":"<div><div>Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) is a newly recognized provisional entity in the fifth edition of the WHO Classification of Central Nervous System Tumors, typically found in pediatric patients with supratentorial disease. We describe a male in his forties who presented with recurrent seizures and was found to have a heavily calcified lesion in the left temporal lobe and an additional lesion in the sacral region of the thecal sac; tissue biopsy of the sacral lesion demonstrated an oligodendroglioma-like morphology, strong synaptophysin and OLIG2 expression, and absent widespread GFAP staining, consistent with DGONC. This represents an unusual occurrence of DGONC outside the supratentorial region, with imaging findings that mimicked a chronic inflammatory process. Radiologists should be aware of the potential for DGONC to present in atypical locations and should consider it in the differential diagnosis of apparently non-neoplastic lesions.</div></div>","PeriodicalId":53472,"journal":{"name":"Radiology Case Reports","volume":"20 8","pages":"Pages 3698-3702"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1930043325003632","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) is a newly recognized provisional entity in the fifth edition of the WHO Classification of Central Nervous System Tumors, typically found in pediatric patients with supratentorial disease. We describe a male in his forties who presented with recurrent seizures and was found to have a heavily calcified lesion in the left temporal lobe and an additional lesion in the sacral region of the thecal sac; tissue biopsy of the sacral lesion demonstrated an oligodendroglioma-like morphology, strong synaptophysin and OLIG2 expression, and absent widespread GFAP staining, consistent with DGONC. This represents an unusual occurrence of DGONC outside the supratentorial region, with imaging findings that mimicked a chronic inflammatory process. Radiologists should be aware of the potential for DGONC to present in atypical locations and should consider it in the differential diagnosis of apparently non-neoplastic lesions.

查看原文本刊更多论文

具有少突胶质细胞瘤样特征和核团簇的脑外弥漫性胶质细胞瘤的独特病例

具有少突胶质细胞瘤样特征和核团簇的弥漫性胶质细胞肿瘤（DGONC）是世卫组织中枢神经系统肿瘤分类第五版中新认可的临时实体，通常见于幕上疾病的儿科患者。我们描述了一名40多岁的男性，他出现了反复发作，发现左颞叶有严重钙化的病变，在骶区有一个额外的病变。骶骨病变组织活检显示少突胶质细胞瘤样形态，强突触素和OLIG2表达，无广泛的GFAP染色，与DGONC一致。这是一种不寻常的发生在幕上区域外的DGONC，其成像结果模拟了慢性炎症过程。放射科医生应该意识到DGONC出现在非典型部位的可能性，并应在明显非肿瘤性病变的鉴别诊断中考虑它。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.