Cuirong Xiao, Xiukuan Xu, Yayan Lin, Hong Kang, Honghui Zhang
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引用次数: 0
Abstract
Background
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis with limited therapeutic options for refractory or recurrent cases. This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with microneedling in VLS management.
Methods
Sixty-four VLS patients (diagnosed from January 2019 to December 2023) underwent ALA-PDT (incubation: 3 hours; irradiation: 635 nm, 100 mW/cm²) combined with microneedling (0.5 mm depth) every 2 weeks for 6 sessions. Outcomes included modified mLSSI score, ISSVD severity grading, Dermatology Life Quality Index (DLQI), dyspareunia Visual Analog Scale (VAS), adverse events, and 6-month recurrence rates.
Results
At 12 weeks, the total efficacy rate reached 92.19 % (59/64). mLSSI scores significantly decreased from 9.07±2.32 to 2.42±1.79 (P < 0.001), with erosion/fissure improvement being most pronounced (86.29 % reduction). ISSVD grading showed complete resolution of severe cases (baseline: 85.94 % vs. 0 % post-treatment), with 90.63 % downgraded to mild. Subgroup analysis revealed superior outcomes in patients with disease duration <1 year (baseline mLSSI: 7.68±2.29 vs. 9.97±1.87 in a long-duration group; t = 4.382, P < 0.0001), particularly in skin texture recovery (90.59 % vs. 83.72 %). DLQI scores decreased by 73.74 % (15.04±2.80 to 3.95±2.02), and 88.89 % (24/27) of patients reported dyspareunia relief (VAS: 5.64±2.58 to 1.50±1.63). Recurrence occurred in 21.88 % (14/64) at 6 months, with no symptom exacerbation (P > 0.05). Only 5 cases (7.81 %) experienced transient erythema, and no severe adverse events were observed.
Conclusion
ALA-PDT combined with microneedling achieves rapid and sustained symptom remission, improves quality of life, and demonstrates excellent safety in refractory VLS. Early intervention (disease duration <1 year) correlates with superior therapeutic outcomes. This combination therapy represents a promising strategy for PDT-enhanced VLS management.
期刊介绍:
Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.