Surgery combined with endoscopic photodynamic therapy for simultaneous double primary early carcinomas of the esophagus and cardia: a case report

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-05-07 DOI:10.1016/j.pdpdt.2025.104616

Zhu-Xin Chen, Hao Chen, Hong Wei, Ling Chen, Guo-Qing Shi

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Abstract

Background

Known as double primary cancers or duplicated cancers, are the simultaneous occurrence of two or more primary malignancies with different histological type. The location and stage of each tumor determine the degree of complexity of treatment. Conventional methods pose great difficulties since a single modality is usually inadequate to reach total eradication.

Case Summary

This paper addresses a 66-year-old male patient diagnosed with an esophageal tumor whose presence had been observed for more than one month without any particular symptoms or signs. The patient presented an unusual example of dual primary early carcinoma involving the cardia and the upper esophagus. Given single-modality techniques were insufficient for total eradication, the tumor in the upper esophagus, which was proximally to the neck, presented special difficulties for conventional treatment. We followed a thorough treatment schedule combining endoscopic photodynamic therapy with surgical resection. With no appreciable disease progression or complications noted over a 32-month follow-up period, this strategy produced good clinical results.

Conclusion

In this case, surgical intervention and photodynamic therapy worked well, providing new optionsfor treating similar clinical situations.

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手术联合内镜光动力治疗食管贲门双原发早期癌1例

背景：双原发癌或重复癌是指两种或两种以上不同组织学类型的原发恶性肿瘤同时发生。每个肿瘤的位置和分期决定了治疗的复杂程度。常规方法有很大的困难，因为单一方式通常不足以达到完全根除。病例总结：本文报告一位66岁男性患者，诊断为食道肿瘤，其存在观察超过一个月，无任何特殊症状或体征。患者表现为不寻常的双原发早期癌累及贲门及食道上部。由于单模态技术不足以完全根除，食管上部靠近颈部的肿瘤在常规治疗中表现出特殊的困难。我们遵循完整的治疗计划，结合内窥镜光动力治疗和手术切除。在32个月的随访期间没有发现明显的疾病进展或并发症，该策略产生了良好的临床结果。结论本病例手术干预结合光动力治疗效果良好，为治疗类似临床情况提供了新的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.