Health-related quality of life of patients with rifampicin-resistant/multidrug-resistant tuberculosis in Vietnam: a prospective follow-up study

IF 1.7 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-05-08 DOI:10.1016/j.cegh.2025.102054

Nguyen Vu Anh Thu , Cao Nguyen Hoai Thuong , Trinh Hoang Duy , Ngo Thi Thuy Dung

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引用次数: 0

Abstract

Background

Currently, the management of rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) primarily focuses on clinical characteristics and microbiological indicators. However, the disease also negatively impacts patients' psychological, economic, and social well-being. Thus, shifting our attention toward health-related quality of life (HRQOL) is essential.

Method

This was a prospective follow-up study conducted within government programmatic management of drug-resistant tuberculosis clinics in seven provinces of Vietnam. HRQOL was assessed at the baseline and after six months of treatment using the SF-36 version 2.0 questionnaire.

Result

A total of 180 patients with RR/MDR-TB completed the SF-36 version 2.0 survey at two time points. The physical component summary (PCS) scores at these two time points were 42.0 ± 8.4 and 44.2 ± 10.5, while the mental component summary (MCS) scores were 41.7 ± 9.0 and 49.8 ± 11.4, respectively. Following multivariable analysis, educational level and marital status were found to be associated with changes in PCS scores from baseline to six months of treatment. Conversely, age, comorbidity, and tuberculosis treatment category were related to changes in MCS scores.

Conclusion

Treatment for RR/MDR-TB has a positive impact on the HRQOL of patients. However, the PCS score after six months of treatment remained low. Therefore, incorporating appropriate exercise regimens, physical therapy measures, and rehabilitation strategies tailored to the needs and capabilities of each patient is essential to enhance their physical health.

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越南利福平耐药/耐多药结核病患者的健康相关生活质量：一项前瞻性随访研究

目前，利福平耐药/耐多药结核病（RR/MDR-TB）的管理主要集中在临床特征和微生物指标上。然而，这种疾病也会对患者的心理、经济和社会福祉产生负面影响。因此，将我们的注意力转向与健康相关的生活质量（HRQOL）是至关重要的。方法对越南7个省的耐药结核病门诊进行前瞻性随访研究。在基线和治疗6个月后使用SF-36 2.0版问卷评估HRQOL。结果共有180例RR/MDR-TB患者在两个时间点完成了SF-36 2.0版调查。生理成分总结（PCS）评分分别为42.0±8.4分和44.2±10.5分，精神成分总结（MCS）评分分别为41.7±9.0分和49.8±11.4分。通过多变量分析，我们发现教育水平和婚姻状况与PCS评分从基线到治疗六个月的变化有关。相反，年龄、合并症和结核病治疗类别与MCS评分的变化有关。结论耐药/耐多药结核治疗对患者HRQOL有积极影响。然而，治疗六个月后的PCS评分仍然很低。因此，结合适当的运动方案、物理治疗措施和康复策略，根据每个患者的需求和能力进行调整，对于增强他们的身体健康至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.