Modulation of Sirtuins to address aging related disorders through the use of selected phytochemicals

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-05-12 DOI:10.1016/j.phymed.2025.156648

Jing Wang , Yaoyao Ren , Shengtao Qu

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引用次数: 0

Abstract

Background

Aging is a complex phenomenon involving oxidative stress, inflammation, and cellular damage subsequently leading to various disorders, such as cardiovascular diseases, neurodegenerative disorders, diabetes, and cancer. Sirtuin (SIRT) proteins are one of the major molecular factors that affect human aging. Sirtuins are a class of NAD⁺-dependent enzymes that control oxidative stress response, DNA damage repair, inflammation and metabolism, all of which are involved in aging and age-related diseases.

Purpose

The objective of this review is to elucidate the potential role of SIRT in the aging process and modulation of SIRT pathway through selected phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol.

Results

Studies convincedly revealed that SIRT pathway represents a promising avenue for extending the human health span and addressing age-related conditions. Phytochemicals like Curcumin, Resveratrol, Quercetin, and Kaempferol have shown excellent potential to mediate aging effects through their potent antioxidant, anti-inflammatory, and regulatory activities. These potent bioactive compounds enhance oxidative stress response, genomic integrity, neuroprotective and anti-inflammatory activities through SIRT pathway modulation. Furthermore, in addition to antiaging effects, other therapeutic benefits are also associated with each compound including nervous disorders, cancer, and metabolic disorders are also briefly highlighted. Studies reported convincing evidence that Curcumin, Resveratrol, Quercetin, and Kaempferol, effectively modulate SIRT expression/activity leading to improved cell stress tolerance, reduced oxidation and enhanced metabolic state.

Conclusions

Collectively, studies revealed the comprehensive nutraceutical significance of Curcumin, Resveratrol, Quercetin, and Kaempferol as anti-aging therapeutics and warrant future studies to exploit the full potential of these natural compounds.

Abstract Image

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通过使用选定的植物化学物质来调节Sirtuins以解决与衰老相关的疾病

衰老是一种复杂的现象，涉及氧化应激、炎症和细胞损伤，随后导致各种疾病，如心血管疾病、神经退行性疾病、糖尿病和癌症。Sirtuin （SIRT）蛋白是影响人类衰老的主要分子因子之一。Sirtuins是一类依赖NAD+的酶，控制氧化应激反应、DNA损伤修复、炎症和代谢，所有这些都与衰老和年龄相关疾病有关。目的通过姜黄素、白藜芦醇、槲皮素和山奈酚等植物化学物质，探讨SIRT在衰老过程中的潜在作用，以及SIRT通路的调控机制。研究令人信服地表明，SIRT途径代表了延长人类健康跨度和解决年龄相关疾病的有希望的途径。姜黄素、白藜芦醇、槲皮素和山奈酚等植物化学物质通过其有效的抗氧化、抗炎和调节活性，显示出极好的调节衰老作用的潜力。这些有效的生物活性化合物通过SIRT通路调节增强氧化应激反应、基因组完整性、神经保护和抗炎活性。此外，除了抗衰老作用外，每种化合物的其他治疗益处也与神经紊乱，癌症和代谢紊乱有关，也简要地强调了这一点。研究报告了令人信服的证据，姜黄素、白藜芦醇、槲皮素和山奈酚有效地调节SIRT的表达/活性，从而提高细胞的应激耐受性，减少氧化和增强代谢状态。总的来说，研究揭示了姜黄素、白藜芦醇、槲皮素和山奈酚作为抗衰老药物的综合营养价值，并保证了未来研究充分利用这些天然化合物的潜力。

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.