Gauthier Desmyttere , Stéphane Ralandison , Gilles Dusfour , Lionel Moulis , Maïlis Amico , Marc Julia , Yves-Marie Pers , Christian Jorgensen
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引用次数: 0
Abstract
Background
Axial spondyloarthritis is a chronic rheumatic disease which impacts spinal mobility and physical functions, including gait. However, current clinical assessments mostly rely on composite indices and questionnaires which involve a degree of subjectivity. This study aimed to assess the discriminant validity of wearable sensors for objective monitoring of axial spondyloarthritis in clinical practice.
Methods
Twenty participants with axial spondyloarthritis and 20 healthy controls were included. Spinal mobility alongside gait were assessed while data were collected using inertial measurement units. Data were compared between the two groups and classification performance was assessed by performing receiver-operating characteristic curve analysis. Finally, correlations between parameters measured through inertial measurement units and clinical measures were also evaluated.
Findings
The axial spondyloarthritis group showed significantly reduced trunk maximum angles in all planes and direction of motion. Gait was characterized by a reduction in cadence (P = 0.004) and speed (P = 0.015). The combination of gait cadence and trunk kinematics enhanced the classification performance (sensitivity = 95 % vs. 55 % with trunk sagittal range of motion alone). Trunk kinematic variables were correlated to mobility items of clinical measures while spatiotemporal gait parameters showed correlations with the disease activity and its functional impact in daily life.
Interpretation
The present study demonstrated the ability of inertial measurement units to effectively discriminate axial spondyloarthritis individuals, with an enhanced classification performance while combining trunk kinematics and gait spatiotemporal parameters. These findings highlight the potential of wearable sensors as valuable tools for assessment and follow-up in clinical practice.
期刊介绍:
Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field.
The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management.
A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly.
Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians.
The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time.
Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.