A combined analysis of spinal mobility and gait spatiotemporal parameters in axial spondyloarthritis using wearable sensors

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-05-07 DOI:10.1016/j.clinbiomech.2025.106555

Gauthier Desmyttere , Stéphane Ralandison , Gilles Dusfour , Lionel Moulis , Maïlis Amico , Marc Julia , Yves-Marie Pers , Christian Jorgensen

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引用次数: 0

Abstract

Background

Axial spondyloarthritis is a chronic rheumatic disease which impacts spinal mobility and physical functions, including gait. However, current clinical assessments mostly rely on composite indices and questionnaires which involve a degree of subjectivity. This study aimed to assess the discriminant validity of wearable sensors for objective monitoring of axial spondyloarthritis in clinical practice.

Methods

Twenty participants with axial spondyloarthritis and 20 healthy controls were included. Spinal mobility alongside gait were assessed while data were collected using inertial measurement units. Data were compared between the two groups and classification performance was assessed by performing receiver-operating characteristic curve analysis. Finally, correlations between parameters measured through inertial measurement units and clinical measures were also evaluated.

Findings

The axial spondyloarthritis group showed significantly reduced trunk maximum angles in all planes and direction of motion. Gait was characterized by a reduction in cadence (P = 0.004) and speed (P = 0.015). The combination of gait cadence and trunk kinematics enhanced the classification performance (sensitivity = 95 % vs. 55 % with trunk sagittal range of motion alone). Trunk kinematic variables were correlated to mobility items of clinical measures while spatiotemporal gait parameters showed correlations with the disease activity and its functional impact in daily life.

Interpretation

The present study demonstrated the ability of inertial measurement units to effectively discriminate axial spondyloarthritis individuals, with an enhanced classification performance while combining trunk kinematics and gait spatiotemporal parameters. These findings highlight the potential of wearable sensors as valuable tools for assessment and follow-up in clinical practice.

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应用可穿戴传感器对轴型脊柱炎患者脊柱活动度和步态时空参数的综合分析

脊柱性关节炎是一种慢性风湿性疾病，影响脊柱活动和身体功能，包括步态。然而，目前的临床评估大多依赖于复合指数和问卷调查，涉及一定程度的主观性。本研究旨在评估可穿戴传感器在临床实践中用于客观监测轴型脊柱炎的判别有效性。方法选取20例轴型脊柱炎患者和20例健康对照者。在使用惯性测量装置收集数据的同时，评估脊柱活动和步态。比较两组患者资料，通过患者-工作特征曲线分析评价两组患者的分类效果。最后，通过惯性测量装置测量的参数与临床测量之间的相关性也进行了评估。结果：中轴性脊柱炎组在所有平面和运动方向上躯干最大角度明显降低。步态的特征是节奏（P = 0.004）和速度（P = 0.015）的减少。步态节奏和躯干运动学的结合提高了分类性能（灵敏度为95%，而单独的躯干矢状运动范围为55%）。躯干运动学变量与临床测量的活动度项目相关，而时空步态参数与疾病活动度及其日常生活功能影响相关。本研究证明了惯性测量单元在结合躯干运动学和步态时空参数的同时，具有增强的分类性能，能够有效地区分轴型脊柱炎个体。这些发现突出了可穿戴传感器在临床实践中作为评估和随访的有价值工具的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.