Assessment of the role of Th17 cell and related biomarkers in periodontitis: A systematic review

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-04-23 DOI:10.1016/j.archoralbio.2025.106272

Sangamithra Sidharthan , Gopalakrishnan D , Supriya Kheur , Subhashree Mohapatra

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引用次数: 0

Abstract

Objective

This study aimed to investigate the evidence for presence of Th17 cells and their biomarkers, and to assess their impact on the immune-inflammatory response in periodontitis.

Materials and methods

An electronic search was performed in MEDLINE (PubMed), SCOPUS, EBSCOhost, and Google Scholar databases from their earliest records to April 2023. Additionally, the reference lists of included articles and grey literature were hand-searched. Study selection and quality assessment of the included articles was performed using the Newcastle-Ottawa scale.

Results

This systematic review included case-control, cross-sectional, and cohort studies published in English, specifically those evaluating the presence and influence of Th17 or its related biomarkers in the progression of periodontal disease. Of the 26,797 articles screened, 47 studies met the eligibility criteria and were included. The studies varied in design, molecular methods, and sample types.

Conclusion

This systematic review confirms the presence of Th17 cells and related biomarkers in periodontal tissues, highlighting their role in the immune-inflammatory response and pathogenesis of periodontitis. The review underscores the need for more comprehensive research to overcome current limitations and effectively translate these findings into clinical practice.

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评估Th17细胞和相关生物标志物在牙周炎中的作用：一项系统综述

目的探讨Th17细胞及其生物标志物在牙周炎中存在的证据，并评估其对免疫炎症反应的影响。材料与方法在MEDLINE （PubMed）、SCOPUS、EBSCOhost和谷歌Scholar数据库中检索最早记录至2023年4月的数据库。此外，人工检索纳入文章和灰色文献的参考文献列表。采用纽卡斯尔-渥太华量表对纳入的文章进行研究选择和质量评估。结果：本系统综述纳入了以英文发表的病例对照、横断面和队列研究，特别是评估Th17或其相关生物标志物在牙周病进展中的存在和影响。在筛选的26,797篇文章中，有47篇研究符合入选标准。这些研究在设计、分子方法和样本类型上各不相同。结论本系统综述证实了Th17细胞及其相关生物标志物在牙周组织中的存在，强调了其在牙周炎免疫炎症反应和发病机制中的作用。该综述强调需要进行更全面的研究，以克服当前的局限性，并有效地将这些发现转化为临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry