Postreceptor Neural Loss in Patients With Chronic Central Serous Chorioretinopathy

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-05-08 DOI:10.1016/j.ajo.2025.04.040

Beatrice Ghezzo , Andrea Ghilardi , Maria Chiara Marena , Pasquale Viggiano , Francesco Boscia , Sonia Serafino , Paola Marolo , Michele Reibaldi , Enrico Borrelli

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引用次数: 0

Abstract

Purpose

To investigate the relationship between ganglion cell layer (GCL) thickness and photoreceptor alterations in eyes with resolved chronic central serous chorioretinopathy (CSC).

Design

Retrospective, cross-sectional “case-control” comparison study.

Methods

We collected data from 70 eyes from 70 male individuals with chronic CSC, pachychoroid pigment epitheliopathy, and healthy controls. Optical coherence tomography imaging was used to assess ellipsoid zone (EZ) reflectivity as a marker of photoreceptor integrity and GCL thickness as an indicator of inner retinal loss. Normalized EZ reflectivity and GCL thickness were compared among groups, and a regression analysis was performed to evaluate the relationship between photoreceptor damage and inner retinal thinning.

Results

CSC eyes exhibited significantly reduced EZ reflectivity compared to pachychoroid pigment epitheliopathy and healthy controls (P < .05). GCL thickness was also reduced in CSC eyes, particularly in the ETDRS inner ring. A significant association was found between EZ reflectivity and GCL thickness in CSC patients (P = .046), suggesting a link between photoreceptor and ganglion cell loss.

Conclusions

Photoreceptor damage in chronic CSC is associated with inner retinal thinning, supporting the hypothesis of postreceptor neural loss. These findings provide further insights into the broader retinal involvement in CSC and may have implications for visual function in affected patients.

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慢性中枢性浆液性脉络膜视网膜病变患者的后受体神经丧失。

目的探讨慢性中枢性浆液性脉络膜视网膜病变（CSC）患者的神经节细胞层（GCL）厚度与光感受器改变的关系。设计回顾性、横断面“病例-对照”比较研究。方法我们收集了70例慢性CSC、厚脉络膜色素上皮病（PPE）男性患者和健康对照者的70只眼睛的数据。使用光学相干断层扫描（OCT）成像评估椭球区（EZ）反射率作为光感受器完整性的标志，GCL厚度作为内视网膜损失的指标。比较各组归一化EZ反射率和GCL厚度，并进行回归分析，评价光感受器损伤与视网膜内变薄的关系。结果scsc组与PPE组和健康对照组相比，EZ反射率显著降低（p<0.05）。CSC眼的GCL厚度也减少，尤其是ETDRS内环。在CSC患者中，EZ反射率与GCL厚度之间存在显著相关性（p=0.046），提示光感受器与神经节细胞损失之间存在联系。结论慢性CSC的光受体损伤与视网膜内变有关，支持受体后神经功能丧失假说。这些发现为进一步了解CSC中更广泛的视网膜受累提供了进一步的见解，并可能对受影响患者的视觉功能有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.