{"title":"Aquasomes: novel crystalline nanocarriers ensuring conformational integrity and high surface exposure for enhanced drug encapsulation and delivery","authors":"Aasha Makavana, Kiran Dudhat","doi":"10.1007/s11051-025-06336-9","DOIUrl":null,"url":null,"abstract":"<div><p>Aquasomes, a novel vesicular drug delivery system, have emerged as an innovative platform in nanobiotechnology, offering significant advantages for the delivery of bioactive substances such as proteins, peptides, hormones, antigens, and genes. Aquasomes are spherical, nanoparticulate carriers with a distinctive three-layered architecture with dimensions ranging from 60 to 300 nm. The foundation of the system is a nanocrystalline solid core that provides structural stability. This core is usually composed of materials including tin oxide, nanocrystalline carbon ceramics (diamonds), or calcium phosphate (brushite). This core is covered with a layer of carbohydrates, generally polyhydroxyl oligomers such as trehalose or cellobiose, which stabilizes and shields the bioactive molecules from dehydration and maintains their structural integrity. Non-covalent and ionic bonding allow drugs to be adsorbed onto the carbohydrate layer, where they retain their biological function and facilitate the delivery of sensitive bio-actives. Transdermal drug delivery and the transportation of molecules including insulin, hemoglobin, enzymes, and antigens have been shown to be enhanced by aquasomes, leading to improved stability, bioavailability, and controlled release. Aquasomes present a viable approach for the targeted and effective administration of a variety of therapeutic agents, especially for sensitive and conformationally unstable proteins, despite difficulties with large-scale synthesis and stability.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 5","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06336-9","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Aquasomes, a novel vesicular drug delivery system, have emerged as an innovative platform in nanobiotechnology, offering significant advantages for the delivery of bioactive substances such as proteins, peptides, hormones, antigens, and genes. Aquasomes are spherical, nanoparticulate carriers with a distinctive three-layered architecture with dimensions ranging from 60 to 300 nm. The foundation of the system is a nanocrystalline solid core that provides structural stability. This core is usually composed of materials including tin oxide, nanocrystalline carbon ceramics (diamonds), or calcium phosphate (brushite). This core is covered with a layer of carbohydrates, generally polyhydroxyl oligomers such as trehalose or cellobiose, which stabilizes and shields the bioactive molecules from dehydration and maintains their structural integrity. Non-covalent and ionic bonding allow drugs to be adsorbed onto the carbohydrate layer, where they retain their biological function and facilitate the delivery of sensitive bio-actives. Transdermal drug delivery and the transportation of molecules including insulin, hemoglobin, enzymes, and antigens have been shown to be enhanced by aquasomes, leading to improved stability, bioavailability, and controlled release. Aquasomes present a viable approach for the targeted and effective administration of a variety of therapeutic agents, especially for sensitive and conformationally unstable proteins, despite difficulties with large-scale synthesis and stability.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
