Reevaluating the role of biological aging in dementia: A retrospective cross-sectional global analysis incorporating confounding factors

IF 2.5 3区医学 Q3 GERIATRICS & GERONTOLOGY

Geriatric Nursing Pub Date : 2025-05-01 DOI:10.1016/j.gerinurse.2025.04.023

Wenpeng You , Fung Kuen Koo , Yanfei Ge , Jacob Sevastidis , Rita (Hui Chen) Chang

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引用次数: 0

Abstract

Background

Biological aging is a key dementia risk factor, but its precise role is debated. This study explores the impact of life expectancy at birth (LEB) on global dementia incidence rates (DIR).

Methods

A retrospective cross-sectional analysis was conducted using population-level data from the World Bank and the Institute for Health Metrics and Evaluation (IHME). Pearson’s r and nonparametric correlations assessed associations, while partial correlation analysis and multiple regression models were employed to adjust for confounders, including economic affluence, genetic predisposition (Ibs), total fertility rate, and urbanization.

Results

LEB showed a strong initial correlation with DIR, explaining 58.05 % of the variance. However, after adjusting for confounders, the independent contribution of LEB to DIR was reduced to 5.95 %. Total fertility rate emerged as the most significant predictor, with LEB being the second strongest. Economic affluence, Ibs, and urbanization were not statistically significant.

Conclusions

This study challenges the view that dementia is solely due to biological aging. While age remains crucial, biological aging accounts for less than 6 % of dementia incidence variance, highlighting the multifaceted nature of dementia risk factors.

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重新评估生物衰老在痴呆中的作用：一项包含混杂因素的回顾性横断面全球分析

生物衰老是痴呆症的一个关键风险因素，但其确切作用仍存在争议。本研究探讨了出生时预期寿命（LEB）对全球痴呆发病率（DIR）的影响。方法利用世界银行和卫生计量与评估研究所（IHME）的人口水平数据进行回顾性横断面分析。Pearson 's r和非参数相关性评估了相关性，而偏相关分析和多元回归模型用于调整混杂因素，包括经济富裕程度、遗传易感性（Ibs）、总生育率和城市化。结果sleb与DIR有较强的初始相关性，解释了58.05%的方差。然而，在调整混杂因素后，LEB对DIR的独立贡献降低到5.95%。总生育率是最重要的预测因素，其次是LEB。经济富裕程度、Ibs和城市化在统计上不显著。本研究挑战了痴呆症完全由生物衰老引起的观点。虽然年龄仍然至关重要，但生物衰老在痴呆症发病率差异中所占的比例不到6%，这凸显了痴呆症风险因素的多面性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatric Nursing 医学-护理

CiteScore

3.80

自引率

7.40%

发文量

257

审稿时长

>12 weeks

期刊介绍： Geriatric Nursing is a comprehensive source for clinical information and management advice relating to the care of older adults. The journal''s peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on care of older adults across the long term continuum. Geriatric Nursing addresses current issues related to drugs, advance directives, staff development and management, legal issues, client and caregiver education, infection control, and other topics. The journal is written specifically for nurses and nurse practitioners who work with older adults in any care setting.