The impact of D-dimer monitoring combined with anticoagulation therapy on pregnancy outcomes and complications in recurrent spontaneous abortion: A case-control study

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-04-18 DOI:10.1016/j.ejogrb.2025.113982

Xi Ye , Yongsheng Li , Chenmin Zheng

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引用次数: 0

Abstract

Background

Recurrent abortion is often linked to coagulation abnormalities. Anticoagulation therapy combined with D-dimer monitoring may improve outcomes. To evaluate the effects of D-dimer monitoring combined with anticoagulation therapy on complications and pregnancy outcomes in recurrent abortion.

Methods

From February 2019 to March 2021, 104 pregnant women with recurrent abortion were divided into a control group (n = 52, placebo) and an observation group (n = 52, D-dimer monitoring + anticoagulation). Uterine artery blood flow (S/D, PI, RI, diastolic notch) and coagulation parameters (PT, TT, APTT, FIB) were assessed before and after treatment. Pregnancy outcomes and complications were recorded.

Results

After treatment, the observation group showed significantly improved uterine artery blood flow (lower S/D, PI, RI, diastolic notch; P < 0.05) and coagulation parameters (higher PT, TT, APTT; P < 0.05). Pregnancy loss and complications (preeclampsia, gestational hypertension, etc.) were significantly lower in the observation group (P < 0.05).

Conclusion

D-dimer monitoring combined with anticoagulation therapy improves uterine artery blood flow, balances coagulation, and reduces complications in recurrent abortion, enhancing pregnancy success rates. This approach is clinically valuable and warrants further application.

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d -二聚体监测联合抗凝治疗对复发性自然流产妊娠结局和并发症的影响：一项病例对照研究

背景：反复流产常与凝血异常有关。抗凝治疗联合d -二聚体监测可能改善预后。评价d -二聚体监测联合抗凝治疗对复发性流产并发症及妊娠结局的影响。方法2019年2月~ 2021年3月，将104例复发性流产孕妇分为对照组（n = 52，采用安慰剂）和观察组（n = 52，采用d -二聚体监测+抗凝）。观察治疗前后子宫动脉血流（S/D、PI、RI、舒张切迹）及凝血指标（PT、TT、APTT、FIB）。记录妊娠结局及并发症。结果治疗后，观察组患者子宫动脉血流明显改善(S/D、PI、RI、舒张切迹降低；P & lt;0.05)和凝血参数(PT、TT、APTT升高；P & lt;0.05)。观察组的妊娠丢失及并发症（子痫前期、妊娠高血压等）明显低于对照组(P <；0.05)。结论d -二聚体监测联合抗凝治疗可改善子宫动脉血流，平衡凝血，减少复发性流产并发症，提高妊娠成功率。该方法具有临床价值，值得进一步应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.