The Role of Temperament Traits in Bipolar Disorder: Neuroimaging Study

IF 4.7 2区医学 Q1 PSYCHIATRY

Depression and Anxiety Pub Date : 2025-05-10 DOI:10.1155/da/5974860

Kirill Markin, Artem Trufanov, Dmitriy Tarumov, Alexander Krasichkov, Yulia Shichkina, Mikhail Kupriyanov

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Abstract

Purpose: This study aimed to identify temperament traits alterations in bipolar disorder (BD) and explore their potential neuroimaging correlates using resting-state functional magnetic resonance imaging.

Methods: We assessed seed-to-voxel alterations in four large-scale brain networks (Salience, Frontoparietal, Default Mode, and SensoriMotor) in 49 patients with BD and 49 healthy individuals according to the difference of temperamental traits (Reward Dependence, Novelty Seeking, Harm Avoidance, and Persistence). Also, we measured the relationship of temperamental traits with the severity of manic and depressive symptoms and impulsivity.

Results: Lower Reward Dependence (t-Welch’s (87.1) = −2.50; p = 0.014) in bipolar patients was associated with increased functional connectivity between Salience Network and Default Mode and FrontoParietal Networks. Higher Novelty Seeking (t-Welch’s (87.3) = 4.37; p < 0.001) was associated with increased functional connectivity within FrontoParietal Network, whereas its functional connectivity with Visual and Dorsal Attention Networks was decreased. Higher Harm Avoidance (t-Welch’s (82.8) = 4.85; p < 0.001) was associated with increased functional connectivity between FrontoParietal Network and basal ganglia. Lower Persistence (U = 998; p = 0.002) was associated with decreased functional connectivity within FrontoParietal Network and with Default Mode Network. Higher persistence in bipolar patients was associated with greater severity of manic symptoms (Spearman’s rho = 0.302, p = 0.018), while lower Reward Dependence was associated with increased severity of depressive symptoms (Pearson’s r = −0.388, p = 0.003). Harm Avoidance negatively correlates with Persistence (Pearson’s r = −0.525, p < 0.001) and positively with reward dependence (Pearson’s r = −0.259, p = 0.036). We also found a negative correlation between impulsivity and Reward Dependence (Pearson’s r = −0.312, p = 0.029) and positive correlation between impulsivity and Novelty Seeking (Pearson’s r = 0.525, p < 0.001).

Conclusions: The findings demonstrate a possible functional neuroimaging basis for altered temperamental traits in patients with bipolar disorder.

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气质特征在双相情感障碍中的作用：神经影像学研究

目的：本研究旨在利用静息状态功能磁共振成像识别双相情感障碍（BD）的气质特征改变，并探讨其潜在的神经影像学相关性。方法：根据49名双相障碍患者和49名健康个体的气质特征（奖励依赖、新奇寻求、伤害回避和持久性）的差异，评估了4个大尺度脑网络（显著性、额顶叶、默认模式和感觉运动）的种子到体素的变化。此外，我们测量了气质特征与躁狂和抑郁症状的严重程度和冲动性的关系。结果：较低的奖励依赖性(t-Welch 's(87.1) =−2.50；p = 0.014)与显著性网络、默认模式和额顶叶网络之间的功能连通性增加有关。更高求新求新(t-Welch 's (87.3) = 4.37；p & lt;0.001)与额顶叶网络功能连通性增加有关，而其与视觉和背侧注意网络的功能连通性下降。更高的伤害避免(t-Welch 's (82.8) = 4.85；p & lt;0.001)与额顶叶网络和基底神经节之间的功能连通性增加有关。低持久性(U = 998；p = 0.002)与额顶叶网络和默认模式网络功能连通性下降有关。双相情感障碍患者的持续程度越高，躁狂症状的严重程度越高（Spearman’s r = 0.302, p = 0.018），而奖励依赖性越低，抑郁症状的严重程度越高（Pearson’s r = - 0.388, p = 0.003）。避免伤害与持久性呈负相关(Pearson’s r = - 0.525, p <；0.001)，与奖励依赖呈正相关（Pearson’s r = - 0.259, p = 0.036）。我们还发现冲动性与奖励依赖呈负相关（Pearson’s r = - 0.312, p = 0.029），冲动性与新奇寻求呈正相关(Pearson’s r = 0.525, p <；0.001)。结论：研究结果证明了双相情感障碍患者气质特征改变的可能的功能神经影像学基础。

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来源期刊

Depression and Anxiety 医学-精神病学

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.