Evaluation of the Effects of Detomidine on Equine Myoelectrical Activity Using Electrointestinography

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2025-04-20 DOI:10.1111/vec.13464

Amelia S. Munsterman, Ana S. Dias Moreira, Jack Kottwitz

{"title":"Evaluation of the Effects of Detomidine on Equine Myoelectrical Activity Using Electrointestinography","authors":"Amelia S. Munsterman, Ana S. Dias Moreira, Jack Kottwitz","doi":"10.1111/vec.13464","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To evaluate the effects of detomidine on equine intestinal slow-wave activity and frequency distribution measured by electrointestinography (EIG).</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>Prospective, experimental study.</p>\n </section>\n \n <section>\n \n <h3> Setting</h3>\n \n <p>University teaching hospital.</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>A convenience sample of twelve 7- to 21-year-old clinically normal horses.</p>\n </section>\n \n <section>\n \n <h3> Interventions</h3>\n \n <p>Horses were randomly assigned to saline control (four horses) or detomidine treatment (eight). After obtaining a 30-min baseline EIG, a saline or detomidine bolus was administered, followed by a constant rate infusion, and another EIG was recorded. Ultrasonographic examinations monitored cecal and left ventral colon contractions. Spectral analysis was performed to evaluate changes in dominant frequency, dominant power, total power, percent frequency distribution, and changes in slow-wave rhythmic activity.</p>\n </section>\n \n <section>\n \n <h3> Measurements and Main Results</h3>\n \n <p>Median (interquartile range [IQR]) dominant frequency in cycles per minute (cpm) was similar for the cecum (2.4 cpm; IQR: 0.51 cpm) and left ventral colon (2.13 cpm; IQR: 0.16 cpm) and unchanged by either treatment (<i>P</i> > 0.074). Compared with saline, which was unchanged, detomidine reduced dominant power ratios for both cecum (0.45; IQR: 0.18) and left ventral colon (0.63; IQR: 0.35; <i>P</i> = 0.002). Detomidine decreased total power for the cecum in the 2–4 cpm frequency range from 55.0% (IQR: 4.4%) to 43.1% (IQR: 6.7%) and for the left ventral colon from 54.4% (IQR: 5.5%) to 27.3% (IQR: 9.3%; <i>P</i> < 0.087). Total power for the cecum was increased in the 8–12 cpm frequency range from 9.6% (IQR: 1.9%) to 18.5% (IQR: 6.6%; <i>P</i> = 0.0044) with detomidine. No change in frequency distribution was noted in controls (<i>P</i> > 0.08). Dominant power correlated with the rate of contractions measured ultrasonographically (<i>P</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Detomidine decreased dominant power ratios for both the cecum and left ventral colon and produced tachyarrhythmias in cecal slow-wave activity. The correlation of dominant power with intestinal contractions supports the clinical development of EIG to diagnose equine motility disorders.</p>\n </section>\n </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 2","pages":"120-130"},"PeriodicalIF":1.1000,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.13464","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary emergency and critical care","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vec.13464","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To evaluate the effects of detomidine on equine intestinal slow-wave activity and frequency distribution measured by electrointestinography (EIG).

Design

Prospective, experimental study.

Setting

University teaching hospital.

Animals

A convenience sample of twelve 7- to 21-year-old clinically normal horses.

Interventions

Horses were randomly assigned to saline control (four horses) or detomidine treatment (eight). After obtaining a 30-min baseline EIG, a saline or detomidine bolus was administered, followed by a constant rate infusion, and another EIG was recorded. Ultrasonographic examinations monitored cecal and left ventral colon contractions. Spectral analysis was performed to evaluate changes in dominant frequency, dominant power, total power, percent frequency distribution, and changes in slow-wave rhythmic activity.

Measurements and Main Results

Median (interquartile range [IQR]) dominant frequency in cycles per minute (cpm) was similar for the cecum (2.4 cpm; IQR: 0.51 cpm) and left ventral colon (2.13 cpm; IQR: 0.16 cpm) and unchanged by either treatment (P > 0.074). Compared with saline, which was unchanged, detomidine reduced dominant power ratios for both cecum (0.45; IQR: 0.18) and left ventral colon (0.63; IQR: 0.35; P = 0.002). Detomidine decreased total power for the cecum in the 2–4 cpm frequency range from 55.0% (IQR: 4.4%) to 43.1% (IQR: 6.7%) and for the left ventral colon from 54.4% (IQR: 5.5%) to 27.3% (IQR: 9.3%; P < 0.087). Total power for the cecum was increased in the 8–12 cpm frequency range from 9.6% (IQR: 1.9%) to 18.5% (IQR: 6.6%; P = 0.0044) with detomidine. No change in frequency distribution was noted in controls (P > 0.08). Dominant power correlated with the rate of contractions measured ultrasonographically (P < 0.001).

Conclusions

Detomidine decreased dominant power ratios for both the cecum and left ventral colon and produced tachyarrhythmias in cecal slow-wave activity. The correlation of dominant power with intestinal contractions supports the clinical development of EIG to diagnose equine motility disorders.

Abstract Image

查看原文本刊更多论文

用肠电图评价德托咪定对马肌电活动的影响

目的探讨托托咪定对马肠电图慢波活动及频率分布的影响。前瞻性实验研究。学校教学医院。选取12匹7- 21岁的临床正常马作为方便样本。干预措施马被随机分配到盐水对照组（4匹马）或托咪定治疗组（8匹马）。在获得30分钟基线EIG后，给予生理盐水或托咪定丸，随后等速输注，并记录另一次EIG。超声检查监测盲肠和左腹结肠收缩。频谱分析评估主导频率、主导功率、总功率、频率分布百分比和慢波节律性活动的变化。盲肠的中位（四分位间距[IQR]）优势频率（每分钟循环数（cpm））相似(2.4 cpm；IQR: 0.51 cpm)和左腹结肠(2.13 cpm；IQR: 0.16 cpm)，两种治疗均无变化(P >；0.074)。与生理盐水相比，托咪定降低了双盲肠的优势功率比(0.45；IQR: 0.18)和左腹结肠(0.63；差:0.35;p = 0.002)。托托咪定使盲肠在2-4 cpm频率范围内的总功率从55.0% （IQR: 4.4%）降至43.1% (IQR: 6.7%)，使左腹结肠的总功率从54.4% （IQR: 5.5%）降至27.3% (IQR: 9.3%)；P & lt;0.087)。盲肠总功率在8-12 cpm频率范围内从9.6% （IQR: 1.9%）增加到18.5% (IQR: 6.6%；P = 0.0044)。对照组的频率分布没有变化(P >；0.08)。优势功率与超声测量的收缩率相关(P <；0.001)。结论德托咪定降低盲肠和左腹结肠的优势功率比，并引起盲肠慢波活动过速性心律失常。优势力量与肠收缩的相关性支持了EIG诊断马运动障碍的临床发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.