Oclacitinib Intoxication

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2025-04-20 DOI:10.1111/vec.13459

Sara Lister, Jessica Kielb Basile, Colette Wegenast

{"title":"Oclacitinib Intoxication","authors":"Sara Lister, Jessica Kielb Basile, Colette Wegenast","doi":"10.1111/vec.13459","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Since the release of chewable flavored oclacitinib, household pets are ingesting larger quantities and are experiencing signs of toxicosis that have not been noted previously.</p>\n </section>\n \n <section>\n \n <h3> Key Findings</h3>\n \n <p>Reports of intoxication have included gastrointestinal signs (vomiting, diarrhea, abdominal pain), cardiovascular signs (rhythm disturbances, hypotension, new onset heart murmur), CNS signs (lethargy, dull mentation, elevated nictitans), acute kidney injury in both dogs and cats, hepatotoxicity, and death.</p>\n </section>\n \n <section>\n \n <h3> Significance</h3>\n \n <p>When overdoses occur with meaningful clinical signs, clinicians are urged to provide proactive monitoring and treatment. Consultation with a poison control center and adverse event reporting to the manufacturer and the Food and Drug Administration are recommended.</p>\n </section>\n </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"35 2","pages":"176-177"},"PeriodicalIF":1.1000,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/vec.13459","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary emergency and critical care","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vec.13459","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Since the release of chewable flavored oclacitinib, household pets are ingesting larger quantities and are experiencing signs of toxicosis that have not been noted previously.

Key Findings

Reports of intoxication have included gastrointestinal signs (vomiting, diarrhea, abdominal pain), cardiovascular signs (rhythm disturbances, hypotension, new onset heart murmur), CNS signs (lethargy, dull mentation, elevated nictitans), acute kidney injury in both dogs and cats, hepatotoxicity, and death.

Significance

When overdoses occur with meaningful clinical signs, clinicians are urged to provide proactive monitoring and treatment. Consultation with a poison control center and adverse event reporting to the manufacturer and the Food and Drug Administration are recommended.

查看原文本刊更多论文

Oclacitinib中毒

背景：自从咀嚼味奥克拉替尼上市以来，家庭宠物摄入了大量的奥克拉替尼，并且出现了以前没有注意到的中毒症状。中毒的报告包括胃肠道症状（呕吐、腹泻、腹痛）、心血管症状（节律障碍、低血压、新发心脏杂音）、中枢神经系统症状（嗜睡、精神迟钝、尼古丁升高）、狗和猫的急性肾损伤、肝毒性和死亡。当过量用药出现有意义的临床症状时，临床医生被敦促提供积极的监测和治疗。建议向中毒控制中心咨询，并向制造商和食品和药物管理局报告不良事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.