The role of per- and polyfluoroalkyl substances in cognitive impairment and dementia

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-05-09 DOI:10.1002/alz.70226

Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan, Tatjana Rundek

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引用次数: 0

Abstract

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic and cardiometabolic effects of PFAS are well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on PFAS in relation to cognitive impairment and dementia are weak, limited, and inconsistent. This report reviews the literature on PFAS and cognitive impairment and provides a rationale and overview of the PFAS VascCog Longitudinal Study, a new study using the population-based Northern Manhattan Study cohort, to prospectively examine serum concentrations of 13 PFAS in relation to lipids, carotid atherosclerosis, cognitive impairment, and dementia. We hypothesize that PFAS deleteriously impact cognition through a pathway involving hyperlipidemia and atherosclerosis. Rigorous examination of PFAS exposure in relation to dementia is needed to inform public health policies on PFAS-containing products, support regulations to reduce community exposure, and provide new avenues to protect cognitive health and impact dementia at the individual and community levels.

Highlights

PFAS exposure increases cardiometabolic risk factors and neurotoxicity.
Data on PFAS in relation to cognitive health is limited, weak, and controversial.
We hypothesize that PFAS exposure increases dementia risk.
We hypothesize a mechanistic pathway involving hyperlipidemia and atherosclerosis.
Rigorous study of PFAS exposure and dementia risk can inform public health policy.

Abstract Image

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全氟烷基和多氟烷基物质在认知障碍和痴呆中的作用

全氟和多氟烷基物质（PFAS）是普遍存在的持久性有机污染物。PFAS的神经毒性和心脏代谢作用已被充分证明，这导致了暴露于PFAS会增加痴呆风险的假设。然而，关于PFAS与认知障碍和痴呆的关系的经验数据是薄弱的、有限的和不一致的。本报告回顾了关于PFAS和认知障碍的文献，并提供了PFAS VascCog纵向研究的基本原理和概述，PFAS VascCog纵向研究是一项基于人群的北曼哈顿研究队列的新研究，前瞻性地研究了13种PFAS的血清浓度与血脂、颈动脉粥样硬化、认知障碍和痴呆的关系。我们假设PFAS通过涉及高脂血症和动脉粥样硬化的途径对认知产生有害影响。需要严格审查PFAS暴露与痴呆症的关系，以便为有关含PFAS产品的公共卫生政策提供信息，支持减少社区暴露的法规，并提供在个人和社区层面保护认知健康和影响痴呆症的新途径。强调PFAS暴露会增加心脏代谢危险因素和神经毒性。关于PFAS与认知健康的关系的数据是有限的、薄弱的和有争议的。我们假设PFAS暴露会增加痴呆风险。我们假设一个涉及高脂血症和动脉粥样硬化的机制途径。对PFAS暴露与痴呆风险的严格研究可以为公共卫生政策提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.