Optimization of a plasmonic biosensor using BSA layer for colorectal cancer detection under optimum radiation damping

IF 2 3区物理与天体物理 Q3 OPTICS

Applied Physics B Pub Date : 2025-05-10 DOI:10.1007/s00340-025-08483-2

Sudhir Shukla, D. K. Dwivedi, Pooja Lohia

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Abstract

A theoretical and simulation based plasmonic sensor is proposed for the detection of colorectal cancer in the near infrared (NIR) region. Plasmonic metal made of silver (Ag) is considered at the top of a calcium fluoride (CaF2) prism. The top layer is bovine serum albumin (BSA) which will act as linker for colorectal tissues. The goal of the simulation is to maximize radiative damping and attain optimum radiation damping (ORD) conditions using Ag–KTaO₃–BSA heterojunction to obtain highest possible figure of merit (FOM). The optimization process involves the variation of Ag and KTaO₃ layer thicknesses (i.e. d_M and d_A respectively) as well as the operating wavelength (λ) in the NIR (nearby 1000 nm) using 2D simulation approach. After concurrent variation of thicknesses, a high value of FOM about 6551 RIU^− 1 at d₁ = 47.7 nm, d₂ = 2.4 nm and λ = 1006.8 nm has been obtained. This can be treated as a condition of ORD. Power loss ratio (PLR), electric field enhancement factor (FEF) and Rayleigh scattering factor (RSF) are calculated to be 3.134, 1.0792 and 0.97 μm^− 4 respectively. Overall sensor performance, examined by combined performance factor (CPF) for the proposed sensor is 22684.02 µm⁴/RIU.

Graphical Abstract

查看原文本刊更多论文

基于BSA层的等离子体生物传感器在最佳辐射阻尼下的结肠直肠癌检测优化

提出了一种基于理论和仿真的近红外区域结直肠癌等离子体传感器。在氟化钙（CaF2）棱镜的顶部考虑由银（Ag）制成的等离子体金属。最上层是牛血清白蛋白（BSA），它将作为结直肠组织的连接体。模拟的目标是利用Ag-KTaO3-BSA异质结最大化辐射阻尼并获得最佳辐射阻尼（ORD）条件，以获得最高可能的优值（FOM）。优化过程涉及到Ag和KTaO3层厚度（分别为dM和dA）的变化以及近红外（1000 nm附近）工作波长（λ）的二维模拟方法。同时改变厚度后，在d1 = 47.7 nm、d2 = 2.4 nm和λ = 1006.8 nm处，FOM值达到6551 RIU−1左右。功率损耗比（PLR）、电场增强因子（FEF）和瑞利散射因子（RSF）分别为3.134、1.0792和0.97 μm−4。该传感器的综合性能因子（CPF）为22684.02µm4/RIU。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Physics B 物理-光学

CiteScore

4.00

自引率

4.80%

发文量

202

审稿时长

3.0 months

期刊介绍： Features publication of experimental and theoretical investigations in applied physics Offers invited reviews in addition to regular papers Coverage includes laser physics, linear and nonlinear optics, ultrafast phenomena, photonic devices, optical and laser materials, quantum optics, laser spectroscopy of atoms, molecules and clusters, and more 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Publishing essential research results in two of the most important areas of applied physics, both Applied Physics sections figure among the top most cited journals in this field. In addition to regular papers Applied Physics B: Lasers and Optics features invited reviews. Fields of topical interest are covered by feature issues. The journal also includes a rapid communication section for the speedy publication of important and particularly interesting results.