Study of hemocompatibility and antioxidant activity of calcium-copper titanate powders

Abstract

The precursor of the CaCu₃Ti₄O₁₂ (CCTO) ceramic powder was obtained by solid-phase synthesis. The synthesized powder was thermally treated at 800 and 1100 ^°C in order to study its biological activity. A research of the effect of CCTO on human blood cells was carried out using the example of a certain number of women in a medical institution. It was found that the synthesized powders were hemocompatible and did not affect the spontaneous aggregation of erythrocytes. In addition, the CCTO suspension was found to have an effect on platelet aggregation. CCTO powder calcined at 800 °C inhibited platelet aggregation more strongly than that calcined at 1100 °C. Using chemiluminescent analysis, an increase in the antioxidant activity of blood serum was detected due to the presence of CCTO powders. In the course of research, we tried to find a correlation between the biological activity of powders and their physicochemical properties. For this, dynamic light scattering, scanning electron microscopy, EDX analysis, X-ray diffractometry and low-temperature nitrogen adsorption–desorption technique were used to characterize the resulting materials. We hope that the results obtained can be used to study and treat human blood diseases.