Synthesis, and antimicrobial activity of some novel 1, 2, 3-triazol-4-yl conjugated indolin-2-one derivatives

Abstract

A series of (E)-3-((2-methoxynaphthalen-1-yl)methylene)-1-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)indolin-2-ones (7(a–l)) compounds were synthesized by using available starting materials such as (E)-3-((2-methoxynaphthalen-1-yl)methylene)indolin-2-one (4), which in-turn leads to the formation of active propargyl precursor and finally undergoes click reaction (active alkyne and different aryl azides) to get compound formula 7(a–l). Further, the synthesized compounds 7(a–l) were studied for in-vitro antimicrobial screening against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa bacterial strains, as well as Fusarium oxysporum and Aspergillus niger as fungal strains by agar disc diffusion method. From in-vitro antimicrobial investigation, it was revealed that among all the synthesized compounds, 7c, 7b, 7e, 7 g, and 7 h showed promising antibacterial activity and comparable with the standard drugs.