Photobiomodulation Ameliorates Neuronal Damage in an Amyloid-Beta Induced Rat Model

IF 4.3 2区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Journal of Selected Topics in Quantum Electronics Pub Date : 2025-04-25 DOI:10.1109/JSTQE.2025.3564366

Na Li;Na Liu;Yutong Ye;Haoxin Shi;Jia Shi;Guoshuai Luo;Jun Guo;Yi Liu;Hongli Chen

引用次数: 0

Abstract

Photobiomodulation (PBM), as a novel noninvasive therapy, has been extensively employed in neurodegenerative disorder research. However, its mechanism of action in Alzheimer's disease (AD) management remains unclear. In this study, a rat model of AD was constructed by administering amyloid-beta (Aβ) intracerebrally, and the influence of 808 nm phototherapy-mediated PBM on AD was explored. The findings indicated that PBM performed a neuroprotective function by reducing neuronal damage in AD and ameliorating cognitive function, mediated by the suppression of Aβ induced neuroinflammation and neuronal apoptosis. This investigation underscores the critical role of PBM in ameliorating Aβ-induced neuronal damage. It provides a theoretical basis for the advancement of near-infrared light application in neurodegenerative disorders.

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光生物调节改善β淀粉样蛋白诱导的大鼠模型的神经元损伤

光生物调节作为一种新型的无创治疗手段，在神经退行性疾病的研究中得到了广泛的应用。然而，其在阿尔茨海默病（AD）治疗中的作用机制尚不清楚。本研究采用β淀粉样蛋白（a β）脑内注射建立大鼠AD模型，探讨808 nm光疗介导的PBM对AD的影响。研究结果表明，PBM通过抑制a β诱导的神经炎症和神经元凋亡，减少AD患者的神经元损伤，改善认知功能，从而发挥神经保护功能。这项研究强调了PBM在改善a β诱导的神经元损伤中的关键作用。为推进近红外光在神经退行性疾病中的应用提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Journal of Selected Topics in Quantum Electronics 工程技术-工程：电子与电气

CiteScore

10.60

自引率

2.00%

发文量

212

审稿时长

3 months

期刊介绍： Papers published in the IEEE Journal of Selected Topics in Quantum Electronics fall within the broad field of science and technology of quantum electronics of a device, subsystem, or system-oriented nature. Each issue is devoted to a specific topic within this broad spectrum. Announcements of the topical areas planned for future issues, along with deadlines for receipt of manuscripts, are published in this Journal and in the IEEE Journal of Quantum Electronics. Generally, the scope of manuscripts appropriate to this Journal is the same as that for the IEEE Journal of Quantum Electronics. Manuscripts are published that report original theoretical and/or experimental research results that advance the scientific and technological base of quantum electronics devices, systems, or applications. The Journal is dedicated toward publishing research results that advance the state of the art or add to the understanding of the generation, amplification, modulation, detection, waveguiding, or propagation characteristics of coherent electromagnetic radiation having sub-millimeter and shorter wavelengths. In order to be suitable for publication in this Journal, the content of manuscripts concerned with subject-related research must have a potential impact on advancing the technological base of quantum electronic devices, systems, and/or applications. Potential authors of subject-related research have the responsibility of pointing out this potential impact. System-oriented manuscripts must be concerned with systems that perform a function previously unavailable or that outperform previously established systems that did not use quantum electronic components or concepts. Tutorial and review papers are by invitation only.