A self-powered smart woundplast for real-time monitoring and on-demand treatment of wound infection

IF 4.1 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-05-08 DOI:10.1016/j.sna.2025.116676

Zhonglin Liu , Ruijie Chen , Rui Lin, Xianchun Jin, Shan Liang, Xinyu Xue, Zhihe Long, Lili Xing

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Abstract

It is very important for the skin injury to realize real-time detection and on-demand treatment of infected wounds. In this study, we develop a self-powered smart woundplast integrating infection monitoring with on-demand drug delivery. The smart woundplast comprises a power supply unit that can harvest mechanical energy from the wearer and convert it into electricity. A temperature measurement unit, consisting of a skin thermometer and a wound thermometer, evaluates wound infection in real time by detecting temperature. A data processing module continuously analyzes temperature data and drives drug release when wound infection is detected. A drug delivery unit employs a three-electrode structure to achieve uniform drug release through iontophoresis. After wearing the smart woundplast for 3 minutes, the temperature difference between the wound and surrounding skin of infected mice is detected to be approximately 1.8°C, whereas that is about 1°C in uninfected mice. After 10 minutes, the amoxicillin concentration in the wound tissue of infected mice is more than twice that of uninfected mice. These results confirm the realization of real-time monitoring and on-demand treatment. After three days of treatment with the smart woundplast, the average wound healing rate of infected mice reaches 91.6 %, surpassing the blank control group by 60.9 %, confirming the smart woundplast exhibits excellent therapeutic efficacy. This smart woundplast presents a novel concept of intelligent treatment of infected wounds combined with self-powered technology.

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一种自供电的智能创面贴，用于实时监测和按需治疗伤口感染

实现感染创面的实时检测和按需治疗对皮肤损伤具有十分重要的意义。在这项研究中，我们开发了一种自供电的智能伤口贴膜，将感染监测与按需给药结合起来。智能创面包括一个电源单元，可以从佩戴者那里收集机械能并将其转化为电能。一种温度测量单元，由皮肤温度计和伤口温度计组成，通过检测温度实时评估伤口感染。数据处理模块连续分析温度数据，并在检测到伤口感染时驱动药物释放。一种药物递送单元采用三电极结构，通过离子透入实现药物均匀释放。佩戴智能创面贴3 分钟后，检测到感染小鼠伤口与周围皮肤的温差约为1.8°C，而未感染小鼠的温差约为1°C。10 分钟后，感染小鼠伤口组织中的阿莫西林浓度是未感染小鼠的两倍以上。这些结果证实了实时监测和按需治疗的实现。经过3天的治疗，感染小鼠的平均创面愈合率达到91.6 %，超过空白对照组60.9 %，证实了智能创面具有良好的治疗效果。这款智能创面机结合自供电技术，提出了一种智能治疗感染伤口的新概念。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...