Surface molecularly imprinted polymer nanocatalytic probes for scattering spectral analysis

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-05-06 DOI:10.1016/j.trac.2025.118283

Jingjing Li , Zhiqiang Wang , Guiqing Wen , Aihui Liang , Zhiliang Jiang

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引用次数: 0

Abstract

Surface molecularly imprinted polymers (SMIPs) offer efficient capture and specific recognition of target molecules by creating three-dimensional recognition sites on the polymer surface. SMIPs in solution can be combined with resonance Rayleigh scattering (RRS) and surface-enhanced Raman scattering (SERS) techniques for selective, sensitive analysis. SMIP-based nanocatalytic probes (SMIPNCPs) integrate recognition with catalytic amplification, enhancing spectral signals and improving sensitivity. This article introduces the design and synthesis of stable SMIP nanoprobes and SMIPNCPs, including the selection of template molecules, optimization of functional monomers, and the development of nanozymes and nanocatalytic indicator reactions. Drawing on the research work of the authors' group, the review highlights recent advances in SMIPs probe-based RRS/SERS and SMIPNCPs-based RRS/SERS spectral analysis. Finally, the challenges and future directions for the practical application of SMIPNCPs are discussed.

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用于散射光谱分析的表面分子印迹聚合物纳米催化探针

表面分子印迹聚合物（smip）通过在聚合物表面创建三维识别位点，提供了对目标分子的有效捕获和特异性识别。溶液中的smip可以与共振瑞利散射（RRS）和表面增强拉曼散射（SERS）技术相结合，进行选择性、敏感性分析。基于smip的纳米催化探针（smipncp）将识别与催化扩增相结合，增强了光谱信号，提高了灵敏度。本文介绍了稳定的SMIP纳米探针和smipncp的设计与合成，包括模板分子的选择、功能单体的优化、纳米酶和纳米催化指示反应的发展。根据作者小组的研究工作，本文重点介绍了基于smip探针的RRS/SERS和基于smipncps的RRS/SERS光谱分析的最新进展。最后，讨论了smipncp在实际应用中面临的挑战和未来的发展方向。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.