Can levels of HPV vaccine knowledge mitigate HPV vaccine hesitation among guardians of children aged 9–14 years? A moderated mediation model

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-05-10 DOI:10.1016/j.vaccine.2025.127208

Yan Xiong , Chengbing Wu , Yidan Zhang , Dan Guo , Jing Wang , Lijie Du , Le Yang , Jingmin Cheng

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引用次数: 0

Abstract

Purpose

Children aged 9–14 years are the primary target demographic for human papilloma virus (HPV) vaccination, and the hesitancy of guardians in this age group regarding HPV vaccination is likely to significantly impact vaccination rates among children. Understanding the relationship between Levels of HPV Vaccine Knowledge, HPV Vaccine Health Beliefs, and HPV Vaccine Hesitancy is a crucial prerequisite for improving HPV vaccination rates among children aged 9–14.

Method

We recruited 5219 guardians of children aged 9–14 years in Shanxi Province, China, using a multistage random sampling method. Participants completed a questionnaire assessing Levels of HPV Vaccine Knowledge, HPV Vaccine Health Beliefs, HPV Vaccine Hesitancy, and demographic characteristics, including the current vaccination status of children aged 9–14.

Results

Employing the SPSS macro program PROCESS Model 7, we developed a moderated mediation model. The findings of the study reveal the following: 1) A significant direct effect of HPV vaccine knowledge on HPV vaccine hesitancy was observed; 2) The association between HPV vaccine knowledge and HPV vaccine hesitancy is partially mediated by HPV vaccine health beliefs; 3) The place of residence moderates the initial segment of the mediation effect, with HPV vaccine knowledge exerting a stronger positive predictive effect on health beliefs in rural areas.

Conclusion

These results contribute novel insights to the existing literature by elucidating the underlying mechanisms between Levels of HPV Vaccine Knowledge and HPV Vaccine Hesitancy. These findings hold significant implications for enhancing HPV vaccination rates among children aged 9–14.

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HPV疫苗知识水平能否减轻9-14岁儿童监护人对HPV疫苗的犹豫？一个有调节的中介模型

目的：9-14岁的儿童是人乳头瘤病毒（HPV）疫苗接种的主要目标人群，该年龄组的监护人对HPV疫苗接种的犹豫可能会显著影响儿童的疫苗接种率。了解HPV疫苗知识水平、HPV疫苗健康信念和HPV疫苗犹豫之间的关系是提高9-14岁儿童HPV疫苗接种率的关键前提。方法采用多阶段随机抽样方法，在山西省招募5219名9 ~ 14岁儿童的监护人。参与者完成了一份评估HPV疫苗知识水平、HPV疫苗健康信念、HPV疫苗犹豫和人口统计学特征的问卷，包括9-14岁儿童的当前疫苗接种状况。结果采用SPSS宏程序PROCESS Model 7建立了一个有调节的中介模型。研究结果表明：1)HPV疫苗知识对HPV疫苗犹豫有显著的直接影响；2) HPV疫苗知识与HPV疫苗犹豫之间的关系部分由HPV疫苗健康信念介导；3)居住地调节了中介效应的初始段，HPV疫苗知识对农村健康信念的正向预测作用更强。结论这些结果通过阐明HPV疫苗知识水平与HPV疫苗犹豫之间的潜在机制，为现有文献提供了新的见解。这些发现对提高9-14岁儿童的HPV疫苗接种率具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.