Regenerative potential of biopolymers - calcium phosphate osteogenic composites in the healing of an experimental defect of the parietal bone

Q3 Biochemistry, Genetics and Molecular Biology

Biomaterials and biosystems Pub Date : 2025-05-04 DOI:10.1016/j.bbiosy.2025.100112

Leonid Sukhodub, Oleksii Korenkov, Liudmyla Sukhodub, Mariia Kumeda

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Abstract

Given the problem of healing defects of the skull vault, this work is designed to compare in vivo on experimental animals the regenerative potential of osteogenic composite materials different in composition and properties: a) modified with nanostructured hydroxyapatite (HA) and Zn²⁺ ions biopolymer alginate (Alg) matrix (Alg_HA), and b) loaded with nanoparticles (NPs) brushite (dicalcium phosphate dihydrate, DCPD) biopolymer chitosan (CS) matrix (CS_DCPD). Regeneration of the parietal bone defect in rats was studied on the 90th and 140th day using light and electron microscopy. Starting from the 90th day, mature lamellar bone tissue formation was observed in the peripheral parts of both implants, which was not yet detected in animals of the control group (healing under the blood clot). The materials underwent resorption during the experiment and were replaced by regenerated tissues. The complete biocompatibility of both materials and the absence of signs of inflammation have been proven. Alg_HA implantation contributed to faster formation and maturation of bone tissue compared to CS_DCPD.

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生物聚合物-磷酸钙成骨复合材料在实验性顶骨缺损愈合中的再生潜力

针对颅骨拱顶缺损的修复问题，本研究在实验动物体内比较了不同组成和性能的成骨复合材料的再生潜力：a)由纳米结构羟基磷灰石（HA）和Zn2+离子修饰的生物聚合物海藻酸盐（Alg）基质（Alg_HA）和b)负载纳米（NPs）刷石（二水合磷酸二钙，DCPD）生物聚合物壳聚糖（CS）基质（CS_DCPD）。采用光镜和电镜观察大鼠顶骨缺损第90天和第140天的再生情况。从第90天开始，两种种植体的外周部分均观察到成熟的板层骨组织形成，而对照组动物尚未发现这种情况（血凝块下愈合）。在实验过程中，材料被吸收，并被再生组织所取代。两种材料的完全生物相容性和无炎症迹象已被证明。与CS_DCPD相比，植入Alg_HA能更快地形成和成熟骨组织。

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