Isoflavones and lignans with anti-inflammatory activity from Thalictrum baicalense Turcz.

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-05-03 DOI:10.1016/j.fitote.2025.106587

Jinyuan Yang, Zhaojing Chen, Yikun Ren, Chunlei Yuan, Senhua Hu, Yiyang Liu, Dahong Li, Huiming Hua

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Abstract

Phytochemical investigation of Thalictrum baicalense Turcz. roots, traditionally used for inflammatory conditions, led to the isolation of three novel isoflavones, thalibaicalins A-C (1–3), and a new lignan, (7R, 8S, 7′R, 8′S)-9E-feruloylneoolivill (6), alongside six known compounds (4–5, 7–10). Structural characterization was accomplished by HRESIMS, comprehensive NMR analysis, and quantum chemical calculations. Anti-inflammatory evaluation in lipopolysaccharide-stimulated RAW 264.7 macrophages identified potent NO inhibitors, with lignan 6 exhibiting the highest activity (IC₅₀ = 9.56 ± 2.03 μM). This study expands the phytochemical diversity of T. baicalense Turcz. and highlights its potential as a source of anti-inflammatory lead compounds, particularly the highly active lignan derivative.

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黄芩中具有抗炎活性的异黄酮和木脂素。

黄芩的植物化学研究。传统上用于炎症条件的根，导致分离出三种新的异黄酮，thalibaicalins a - c（1-3）和一种新的木脂素，(7R, 8S, 7'R, 8S)-9E-feruloylneoolivill(6)，以及六种已知化合物（4,5,7 - 10）。结构表征由hresms，综合核磁共振分析和量子化学计算完成。脂多糖刺激的RAW 264.7巨噬细胞的抗炎评估发现了有效的NO抑制剂，木脂素6表现出最高的活性（IC50 = 9.56±2.03 μM）。本研究扩大了黄芩的植物化学多样性。并强调其作为抗炎先导化合物来源的潜力，特别是高活性木脂素衍生物。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.