Green analytical chemistry in gabapentin analysis: Methods and sustainability review

IF 4.1 Q1 CHEMISTRY, ANALYTICAL

Talanta Open Pub Date : 2025-05-01 DOI:10.1016/j.talo.2025.100465

Hemraj Sharma , Kanaka Parvathi Kannaiah , Reem Hasan Obaydo , Rita Keshishian , Hemanth Kumar Chanduluru , Kritika Bhattarai , Ashish Acharya

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Abstract

Gabapentin (GP), widely prescribed for seizures and neuropathic pain, requires effective therapeutic monitoring and pharmaceutical quality control. Current analytical methods, such as UV spectrophotometry, HPLC, GC–MS, and LC-MS/MS, often rely on environmentally hazardous solvents and high-energy processes. This review evaluates analytical methods for GP till 2024, focusing on their eco-friendliness using green analytical chemistry (GAC) metrics. The study highlights the lack of concern for solvent toxicity, energy consumption, and waste generation in existing methodologies. Greenness assessment tools like GAPI, MoGAPI, AGREE, BAGI, AES reveal significant gaps in sustainability. This review underscores the need to develop greener analytical techniques for GP and advocate for eco-friendly solvents, reduced waste, and optimized energy use. Integrating GAC principles into analytical practices can enhance sustainability and robustness, reducing the environmental footprint of GP analysis. By compiling this information, the review aims to guide researchers in adopting innovative, eco-conscious methodologies, and aligning analytical procedures with sustainable chemistry goals.

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加巴喷丁分析中的绿色分析化学：方法和可持续性综述

加巴喷丁（GP）广泛用于癫痫发作和神经性疼痛，需要有效的治疗监测和药物质量控制。目前的分析方法，如紫外分光光度法、高效液相色谱法、气相色谱-质谱法和LC-MS/MS，往往依赖于对环境有害的溶剂和高能过程。本文评价了到2024年GP的分析方法，重点是使用绿色分析化学（GAC）指标的生态友好性。该研究强调，在现有的方法中缺乏对溶剂毒性、能源消耗和废物产生的关注。GAPI、MoGAPI、AGREE、BAGI、AES等绿色评估工具揭示了可持续性方面的重大差距。这篇综述强调了开发更环保的GP分析技术的必要性，并倡导环保溶剂，减少浪费和优化能源利用。将GAC原则整合到分析实践中可以增强可持续性和稳健性，减少GP分析的环境足迹。通过汇编这些信息，本文旨在指导研究人员采用创新的、具有生态意识的方法，并使分析过程与可持续化学目标保持一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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