Recent Advances in Metal-Catalyzed Transformations of Acylsilanes via the Activation of C–Si Bonds

Abstract

The field of acylsilane chemistry has witnessed remarkable advancements, particularly in catalytic activation and transformation processes that unveil unique reactivity patterns. This perspective highlights recent breakthroughs in the catalytic manipulation of acylsilanes via oxidative addition of the C–Si bond, with an emphasis on reaction mechanisms, synthetic applications, and emerging strategies in transition-metal catalysis. The unique electronic structure of acylsilanes, characterized by the interaction between the carbonyl group and the silicon, imparts reactivity distinct from other carbonyl compounds, enabling the streamlined synthesis of complex molecules. Key developments discussed include palladium-, rhodium-, and nickel-catalyzed processes, facilitating transformations such as decarbonylation, insertion into the C–Si bond, and siloxycarbene-metal species-mediated reactions. By elucidating the mechanistic underpinnings of these catalytic systems, this perspective offers a foundation for future innovations in acylsilane chemistry.