Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

IF 14.9 1区医学 Q1 NEUROSCIENCES

Molecular Neurodegeneration Pub Date : 2025-05-09 DOI:10.1186/s13024-025-00847-8

John Hardy, Patrick Lewis

引用次数: 0

Abstract

While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

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证据表明小胶质细胞从神经元表达的APP中产生淀粉样蛋白：一种假设

APP主要是神经元表达，而Aβ淀粉样蛋白主要是由小胶质细胞产生的，因为受损膜的清除机制变得不堪负荷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurodegeneration 医学-神经科学

CiteScore

23.00

自引率

4.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Neurodegeneration, an open-access, peer-reviewed journal, comprehensively covers neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and prion diseases, fall under its purview. These disorders, often linked to advanced aging and characterized by varying degrees of dementia, pose a significant public health concern with the growing aging population. Recent strides in understanding the molecular and cellular mechanisms of these neurodegenerative disorders offer valuable insights into their pathogenesis.