Periodontal Inflammation and Serum Inflammatory Markers in Community‐Dwelling Older Adults in Japan: The Otassha Study

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-05-09 DOI:10.1111/jcpe.14177

Masanori Iwasaki, Maki Shirobe, Yuki Ohara, Keiko Motokawa, Takashi Shida, Yoshiko Motohashi, Ayako Edahiro, Hisashi Kawai, Yoshinori Fujiwara, Kazushige Ihara, Yutaka Watanabe, Hiroyuki Sasai, Shuichi Obuchi, Hirohiko Hirano

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Abstract

AimTo investigate the associations between periodontal inflammation—as determined by the periodontal inflamed surface area (PISA)—and serum inflammatory markers in community‐dwelling older adults in Japan.Materials and MethodsThis cross‐sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z‐score (CIMZ) was calculated as the sum of the participants' individual z‐scores for C‐reactive protein (CRP), interleukin‐1beta (IL‐1β), IL‐6 and tumour necrosis factor‐α (TNF‐α). The associations of PISA (quartiles) with individual biomarkers (continuous, log‐transformed) and CIMZ (dichotomized, highest quartile or not) were assessed using linear or Poisson regression models.ResultsCompared with participants in the lowest PISA quartile (Q1), those in Q3 and Q4 had significantly (p < 0.05) higher CRP and IL‐6 levels. Statistically significant linear trends (ptrend < 0.05) across the PISA quartiles were observed for CRP and IL‐6. The multivariable adjusted prevalence ratios (95% confidence intervals) of high CIMZ (reference: Q1) were 1.20 (0.68–2.14), 1.66 (0.96–2.88) and 1.90 (1.08–3.34) (ptrend = 0.01) in individuals in PISA Q2–Q4.ConclusionsOlder adults with high periodontal inflammation had high serum CRP and IL‐6 concentrations and composite summary inflammatory indicator values. Periodontal inflammation is a potential modifiable factor of elevated inflammatory status among older adults in Japan.

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日本社区老年人牙周炎症和血清炎症标志物：奥塔沙研究

目的研究日本社区居住老年人牙周炎症（由牙周炎症表面积（PISA）测定）与血清炎症标志物之间的关系。材料和方法本横断面研究包括470名成年人（平均年龄：73.1岁）。复合炎症标志物z -评分（CIMZ）计算为受试者C -反应蛋白（CRP）、白细胞介素- 1β (IL - 1β)、IL - 6和肿瘤坏死因子- α (TNF - α)的个体z -评分之和。使用线性或泊松回归模型评估PISA（四分位数）与个体生物标志物（连续的，对数变换的）和CIMZ（二分类，最高四分位数或非最高四分位数）的关联。结果与PISA最低四分位数（Q1）的参与者相比，Q3和Q4的参与者具有显著的(p <；0.05) CRP和IL - 6水平升高。统计上显著的线性趋势(ptrend <；0.05)在PISA四分位数中观察到CRP和IL - 6的差异。PISA Q2-Q4个体高CIMZ的多变量校正患病率（95%置信区间：Q1）分别为1.20（0.68-2.14）、1.66（0.96-2.88）和1.90 (1.08-3.34)（p趋势= 0.01）。结论重度牙周炎症患者血清CRP、IL - 6浓度及炎症综合指标均较高。牙周炎症是日本老年人炎症状态升高的潜在可改变因素。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.